Protein Alignment Arp2 and Actl6b

DIOPT Version :10

• Sequence 1: NP_001259621.1
• Gene: Arp2 / 32623
• FlyBaseID: FBgn0011742
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_001412719.1
• Gene: Actl6b / 83766
• MGIID: 1933548
• Length: 434
• Species: Mus musculus
• Alignment Length: 453
• Identity: 129/453 - (28%)
• Similarity: 203/453 - (44%)
• Gaps: 103/453 - (22%)

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEV--------KDLHVDD--LMVG 63
            :|.|.|:..|:.||||.:.|...||:.||   :.|..:.|.:|:        |..|:|.  |.|.
Mouse    14 LVFDIGSFSVRAGYAGEDCPKADFPTTVG---LLAAEEGGGLELEGEKEKKGKIFHIDTNALHVP 75

  Fly    64 DEASQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKM 128
            .:.:      ||..|::||::.:|:....:.|:|:. |.:..:|....:|::|.|.|....|||:
Mouse    76 RDGA------EVMSPLKNGMIEDWECFRAILDHTYS-KHVKSEPNLHPVLMSEAPWNTRAKREKL 133

  Fly   129 IEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRD 193
            .|:|||:|...:.::...||||.:|.|..:|:|:|||...|...||::.:.|.....:..:||..
Mouse   134 TELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDF 198

  Fly   194 ITRYLIKLL------LLRGYAFNHSADFETVR-------IMKEKLCYIG---------------- 229
            |:....:|.      ::..|..   |..|.||       ..||||..:.
Mouse   199 ISMQCRELFQEMAIDIIPPYMI---AAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQ 260

  Fly   230 ----------YDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEG---- 280
                      ||   ||..|...||   .|.:|:|.....|.||...||.||.|.  ||:|
Mouse   261 ASVLQVSDSPYD---EQVAAQMPTV---HYEMPNGYNTDYGAERLRIPEGLFDPS--NVKGLSGN 317

  Fly   281 --PGIAELAFNTIQAADIDIRP--------ELYKHIVLSGGSTMYPGLPSRLEREIKQ-----LY 330
              .|:..:...:|...||||||        .||..::::||:|:..|...||.||:.|     :.
Mouse   318 TMLGVGHVVTTSIGMCDIDIRPVDASPCSQGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMR 382

  Fly   331 LERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQK 393
            |:.:..|.|.:             ||...:|||::||.:...:. .|:|||||:|.|.:.:::
Mouse   383 LKLIASNSTME-------------RKFSPWIGGSILASLGTFQQ-MWISKQEYEEGGKQCVER 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ASKHA_NBD_Arp2	7..393	CDD:466821	129/451 (29%)
Actl6b	NP_001412719.1	Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000269|PubMed:17920018	39..82		11/51 (22%)