DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and POTEJ

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_011509985.1	Gene:	POTEJ / 653781	HGNCID:	37094	Length:	1048	Species:	Homo sapiens

Alignment Length:	386	Identity:	176/386 - (45%)
Similarity:	247/386 - (63%)	Gaps:	20/386 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSL 72
            |:|.|||:|..|.|:||.:.|..:|||:||.|  |....:|     .:|..:..||.||...|.:
Human   680 VLVIDNGSGMCKAGFAGDDAPRAVFPSIVGCP--RQQGMMG-----GMHQKESYVGKEAQSKRGI 737

  Fly    73 LEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYG 137
            |.:.||||:|::.|||||..:|.:|| ..::.:.|....|||||.|:||..|||||.::|||.:.
Human   738 LTLKYPMEHGIITNWDDMEKIWHHTF-YNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFN 801

  Fly   138 FDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLL 202
            ..:.|:||||:|:||..|..:|:|:||||||||..|:|:..||||.|.|||:|||::|.||:|:|
Human   802 TPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKIL 866

  Fly   203 LLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAP 267
            ..|||.|...|:.|.||.:||||||:..|.|.|..:...::.|.:||.||||:||.:..|.|..|
Human   867 TERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMVASSSSLEKSYELPDGQVITISNEWFRCP 931

  Fly   268 EALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLE 332
            ||||||..:.:|..||.|..||:|..:|:|||.:||.:.|||||:|||||:..|:::||..|
Human   932 EALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAAL--- 993

  Fly   333 RVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQK 393
                    ..:..||||..||:||..|::||::||.::..:. .|:|||||.|.|..::.:
Human   994 --------APSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQ-MWISKQEYDESGPSIVHR 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	176/384 (46%)
POTEJ	XP_011509985.1	Ank_2	106..209	CDD:289560
		ANK	130..265	CDD:238125
		ANK repeat	137..166	CDD:293786
		ANK repeat	168..209	CDD:293786
		ANK	206..330	CDD:238125
		ANK repeat	211..242	CDD:293786
		Ank_2	216..308	CDD:289560
		ANK repeat	244..275	CDD:293786
		ANK repeat	277..308	CDD:293786
		NBD_sugar-kinase_HSP70_actin	674..1048	CDD:302596	176/386 (46%)
		ACTIN	678..1048	CDD:214592	176/386 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820