DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and ACTA1

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001091.1	Gene:	ACTA1 / 58	HGNCID:	129	Length:	377	Species:	Homo sapiens

Alignment Length:	392	Identity:	182/392 - (46%)
Similarity:	252/392 - (64%)	Gaps:	20/392 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSKGRNVIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEA 66
            |......:|||||:|.||.|:||.:.|..:|||:||||..:.| .:|      :...|..|||||
Human     3 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGV-MVG------MGQKDSYVGDEA 60

  Fly    67 SQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEV 131
            ...|.:|.:.||:|:|::.|||||..:|.:|| ..::.:.|.....||||.|:||..|||||.::
Human    61 QSKRGILTLKYPIEHGIITNWDDMEKIWHHTF-YNELRVAPEEHPTLLTEAPLNPKANREKMTQI 124

  Fly   132 MFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITR 196
            |||.:...:.|:||||||:|||.|..:|:|:||||||||..|:||.:||||...|||:||||:|.
Human   125 MFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTD 189

  Fly   197 YLIKLLLLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGG 261
            ||:|:|..|||:|..:|:.|.||.:||||||:..|.|.|...|..::.|.:||.||||:||.:|.
Human   190 YLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGN 254

  Fly   262 ERFEAPEALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREI 326
            |||..||.||||..|.:|..||.|..:|:|...|||||.:||.:.|:|||:|||||:..|:::||
Human   255 ERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEI 319

  Fly   327 KQLYLERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVL 391
            ..|           ..:..||:|..||.||..|:|||::||.::..:. .|::||||.|.|..::
Human   320 TAL-----------APSTMKIKIIAPPERKYSVWIGGSILASLSTFQQ-MWITKQEYDEAGPSIV 372

  Fly   392 QK 393
            .:
Human   373 HR 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	181/386 (47%)
ACTA1	NP_001091.1	PTZ00281	4..377	CDD:173506	181/391 (46%)
		Interaction with alpha-actinin. /evidence=ECO:0000250\|UniProtKB:P68135	112..125		7/12 (58%)
		Interaction with alpha-actinin. /evidence=ECO:0000250\|UniProtKB:P68135	360..372		6/11 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820