DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and Actl6a

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_062647.2	Gene:	Actl6a / 56456	MGIID:	1861453	Length:	429	Species:	Mus musculus

Alignment Length:	451	Identity:	128/451 - (28%)
Similarity:	200/451 - (44%)	Gaps:	104/451 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQ----- 68
            :|.|.|:..|:.||||.:.|...||:.:|..:.|      |.....:.:|    ||:..|
Mouse    14 LVFDIGSYTVRAGYAGEDCPKVDFPTAIGVVLER------DDGSTMMEID----GDKGKQGGPTY 68

  Fly    69 ---------LRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDI--DPTNTKILLTEPPMNPT 122
                     .|..:|...|::||:|.:||....:.|:|:   ||.:  :.:...:|::|.|.|..
Mouse    69 YIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTY---KMHVKSEASLHPVLMSEAPWNTR 130

  Fly   123 KNREKMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRL 187
            ..|||:.|:|||.|...:.::...||||.:|.|..:|:::|||...|...||::.:.|.....:.
Mouse   131 AKREKLTELMFEHYSIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAIPVHDGYVLQQGIVKS 195

  Fly   188 DIAGRDITRYLIKLL------LLRGYAFNHSADFETVR-------IMKEKL-------------C 226
            .:||..||....:|.      |:..|..   |..|.||       ..||||             |
Mouse   196 PLAGDFITMQCRELFQEMNIELIPPYMI---ASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNC 257

  Fly   227 YI-------------GYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINV 278
            .|             .||   ||..|...||   .|..|:|.....|.||.:.||.||.|.  ||
Mouse   258 VIQDFQASVLQVSDSTYD---EQVAAQMPTV---HYEFPNGYNCDFGAERLKIPEGLFDPS--NV 314

  Fly   279 EG------PGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQ-----LYLE 332
            :|      .|::.:...::...||||||.||..::::||:|:......||.||:.|     :.|:
Mouse   315 KGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLK 379

  Fly   333 RVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQK 393
            .:..|.|.:             |:...:|||::||.:...:. .|:|||||:|.|.:.:::
Mouse   380 LIANNTTVE-------------RRFSSWIGGSILASLGTFQQ-MWISKQEYEEGGKQCVER 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	128/449 (29%)
Actl6a	NP_062647.2	Actin	11..429	CDD:394979	128/451 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910