Protein Alignment Arp2 and ACTL6B

DIOPT Version :9

• Sequence 1: NP_001259621.1
• Gene: Arp2 / 32623
• FlyBaseID: FBgn0011742
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 129/445 - (28%)
• Similarity: 203/445 - (45%)
• Gaps: 95/445 - (21%)

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEV--------KDLHVDD--LMVG 63
            :|.|.|:..|:.||||.:.|...||:.||   :.|..:.|.:|:        |..|:|.  |.|.
Human    14 LVFDIGSFSVRAGYAGEDCPKADFPTTVG---LLAAEEGGGLELEGDKEKKGKIFHIDTNALHVP 75

  Fly    64 DEASQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKM 128
            .:.:      ||..|::||::.:|:....:.|:|:. |.:..:|....:|::|.|.|....|||:
Human    76 RDGA------EVMSPLKNGMIEDWECFRAILDHTYS-KHVKSEPNLHPVLMSEAPWNTRAKREKL 133

  Fly   129 IEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRD 193
            .|:|||:|...:.::...||||.:|.|..:|:|:|||...|...||::.:.|.....:..:||..
Human   134 TELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDF 198

  Fly   194 ITRYLIKLL------LLRGYAFNHSADFETVR-------IMKEKLCYIG---------------- 229
            |:....:|.      ::..|..   |..|.||       ..||||..:.
Human   199 ISMQCRELFQEMAIDIIPPYMI---AAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQ 260

  Fly   230 ----------YDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPEALFQPHLINVEG---- 280
                      ||   ||..|...||   .|.:|:|.....|.||...||.||.|.  ||:|
Human   261 ASVLQVSDSPYD---EQVAAQMPTV---HYEMPNGYNTDYGAERLRIPEGLFDPS--NVKGLSGN 317

  Fly   281 --PGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQ-----LYLERVLKND 338
              .|:..:...:|...||||||.||..::::||:|:..|...||.||:.|     :.|:.:..|.
Human   318 TMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNS 382

  Fly   339 TEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQK 393
            |.:             ||...:|||::||.:...:. .|:|||||:|.|.:.:::
Human   383 TME-------------RKFSPWIGGSILASLGTFQQ-MWISKQEYEEGGKQCVER 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	129/443 (29%)
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	129/445 (29%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		11/51 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910