DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and POTEE

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001077007.1	Gene:	POTEE / 445582	HGNCID:	33895	Length:	1075	Species:	Homo sapiens

Alignment Length:	386	Identity:	180/386 - (46%)
Similarity:	248/386 - (64%)	Gaps:	20/386 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSL 72
            |:|.|||:|..|.|:||.:.|..:|||:||||  |....:|     .:|..:..||.||...|.:
Human   707 VLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRP--RQQGMMG-----GMHQKESYVGKEAQSKRGI 764

  Fly    73 LEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYG 137
            |.:.||||:|::.|||||..:|.:|| ..::.:.|....|||||.|:||..|||||.::|||.:.
Human   765 LTLKYPMEHGIITNWDDMEKIWHHTF-YNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFN 828

  Fly   138 FDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLL 202
            ..:.|:|||||.:||..|..:|:|:||||||||..|:||..||||.|.|||:|||::..||:|:|
Human   829 TPAMYVAIQAVPSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKIL 893

  Fly   203 LLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAP 267
            ..|||.|...|:.|.||.:||||||:..|.|.|...|..::.|.:||.||||:||.:|.|||..|
Human   894 TERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCP 958

  Fly   268 EALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLE 332
            ||||||..:.:|..||.|..||:|..:|:|||.:||.:.|||||:|||||:..|:::||..|
Human   959 EALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAAL--- 1020

  Fly   333 RVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQGLKVLQK 393
                    ..:..||||..||:||..|::||::||.::..:. .|:|||||.|.|..::.:
Human  1021 --------APSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQ-MWISKQEYDESGPSIVHR 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	180/384 (47%)
POTEE	NP_001077007.1	Ank_4	143..193	CDD:290365
		ANK	167..292	CDD:238125
		ANK 1	172..201
		ANK repeat	174..203	CDD:293786
		Ank_2	177..269	CDD:289560
		ANK repeat	205..236	CDD:293786
		ANK 2	205..234
		ANK	233..357	CDD:238125
		ANK repeat	238..269	CDD:293786
		ANK 3	238..267
		Ank_2	243..335	CDD:289560
		ANK repeat	271..302	CDD:293786
		ANK 4	271..300
		ANK repeat	304..335	CDD:293786
		ANK 5	304..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..530
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..599
		NBD_sugar-kinase_HSP70_actin	701..1075	CDD:302596	180/386 (47%)
		Actin-like	702..1075		180/386 (47%)
		ACTIN	705..1075	CDD:214592	180/386 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820