DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and actr8

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001001400.1	Gene:	actr8 / 326866	ZFINID:	ZDB-GENE-030131-5065	Length:	623	Species:	Danio rerio

Alignment Length:	481	Identity:	88/481 - (18%)
Similarity:	168/481 - (34%)	Gaps:	167/481 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HVDDLMVGDEASQLR--SLLEVSYPMENGVVRNWD-----------DMCHVWDYTFGPKKMDI-- 105
            |..:.:||:||..:.  ....|.:|:..|.:....           |:.|:|.:.. .|.:.|
Zfish   161 HHPEYVVGEEALYVNPTDCYSVHWPVCRGRLNLHSGSGGSLSAVMMDLEHIWTHAL-QKLLQIPL 224

  Fly   106 -DPTNTKILLTEPPMNPTKNREKMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVT 169
             |....:.:|..|.:...::.::::.::..|.||.:..:..::|...:..||.|..|:|.||..|
Zfish   225 KDLKYYRCILLIPDIYNRQHVKEIVNMLLVKMGFSAVVVHQESVCATFGSGLSSACVVDVGDQKT 289

  Fly   170 HICPVYEEFALPHLTRRLDIA--GRDITRYLIKLLLLRGYAF-----NHSADFETVRIMKEKLCY 227
            .:|.|  |..:.|.:.||.:|  |.|:||....|:...|:.:     .:..|...::.:||..|:
Zfish   290 SVCCV--EDGVSHRSSRLCLAYGGSDVTRCFFWLMQRAGFPYRDCQLGNKLDCVLLQQLKESFCH 352

  Fly   228 IGYDIEMEQRLALETTVLVESYTLPDGRV----IKVGGERFEAPEALFQPHLINVEG-------- 280
            :..||...|.....|       ..||..|    :::|.|:.:||..||.|....:.|
Zfish   353 LDQDISGLQDHEFRT-------RFPDSPVLLYQLRLGDEKLQAPMTLFYPAAFGIVGQRMTSLLH 410

  Fly   281 --------------------------------------------PGIAELAFNTIQAADIDI--- 298
                                                        ..:.|::..:....|:|:
Zfish   411 RSQGDAEDPHDEHFLLTTQSKQDQSSKASADRKSFPKPSSFEGESSVCEVSDRSSLGQDLDLGHS 475

  Fly   299 ---------------------------------------------------RPELYKHIVLSGGS 312
                                                               :.::|..|::.||.
Zfish   476 QAECLVGGAETEETPSALLSRKTAMSQFEGKALGIDKAILHSIDSCASDETKRKMYSCILVVGGG 540

  Fly   313 TMYPGLPSRLEREIKQLYLERVLKNDTEKLAKFKIRIEDP---PRRKD-----MVFIGGAVLA-- 367
            .::.|....|:        .|:|   .:....|:..:|..   .|.||     .|:.||:|||
Zfish   541 LLFHGAQEFLQ--------HRIL---NKMPPSFRCMVESVDVITRPKDTDARVCVWKGGSVLACL 594

  Fly   368 EVTKDRDGFWMSKQEYQEQGLKVLQK 393
            :.|::   .|:.::|:|..|:::|::
Zfish   595 DTTQE---LWIHQREWQRFGVRMLRE 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	88/479 (18%)
actr8	NP_001001400.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		NBD_sugar-kinase_HSP70_actin	207..617	CDD:302596	80/433 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..458		0/29 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910