DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and Actl7b

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001020588.1	Gene:	Actl7b / 313183	RGDID:	1305655	Length:	417	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	133/380 - (35%)
Similarity:	208/380 - (54%)	Gaps:	24/380 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSLL 73
            :|.|.|:.:.||||||...||:...|.||:.........||.      ..:..||.|...:.:.|
  Rat    53 LVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDT------FKETYVGHELLNMEASL 111

  Fly    74 EVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYGF 138
            ::..|:::|||.:||.:.::|:|.| ...|.|.|....:|:::||::||.||||..|:|||.:|.
  Rat   112 KLVNPLKHGVVVDWDCIQNIWEYIF-HTAMKILPEEHAVLVSDPPLSPTSNREKYAELMFETFGI 175

  Fly   139 DSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLLL 203
            .:.::..||:|::|:.|..||:|::||.||:|:.|:.|...||.|..|:|.||.|:|.||::||.
  Rat   176 PAMHVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLN 240

  Fly   204 LRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPE 268
            ..|:.|:.. ....:..:|:|.||.....|.|..|.|:.  |...|.||||:||.:|.|||...|
  Rat   241 EAGHKFSDD-HLHIIEHIKKKCCYAALLPEEEMSLGLDE--LHVDYELPDGKVITIGQERFRCSE 302

  Fly   269 ALFQPHLINVEGPGIAELAFNTI-QAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLE 332
            .||:|.|:....||:.||....: :......:.|:..:::|.||.||..|.|.|.:||:..|
  Rat   303 MLFKPSLVGSTQPGLPELTATCLDRCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLL--- 364

  Fly   333 RVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQG 387
              ...|:..:|.       .|.||..|:.||::||.:...:. .|:||:|::|:|
  Rat   365 --CPGDSPTVAA-------APERKTSVWTGGSILASLQAFQQ-LWVSKEEFEERG 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	133/380 (35%)
Actl7b	NP_001020588.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
Actl7b	NP_001020588.1	ACTIN	51..417	CDD:214592	133/380 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900