DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and Actl9b

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001013915.1	Gene:	Actl9b / 292516	RGDID:	1359476	Length:	411	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	121/405 - (29%)
Similarity:	218/405 - (53%)	Gaps:	55/405 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVG-RPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSL 72
            :|.|.|||..|.|:||...||:|..::|| :|..|...:...:|        :.:| ||:..|..
  Rat    47 VVIDMGTGICKMGFAGQTRPTYIVRNIVGCQPKRRTTMEQPKME--------MFIG-EAAHARPE 102

  Fly    73 LEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYG 137
            |.:.:|:.||:|.:|:....:|.:.. ...:.:|..:..:|.|:||.||..||||::||.||...
  Rat   103 LTLMHPVRNGIVVDWEAAEFIWRHIL-ENDLRLDTQDHPLLFTDPPFNPASNREKLVEVAFESLH 166

  Fly   138 FDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLL 202
            ..:.|:|.|:||::||.|.::|:|:|:|.||::..||::.:.||...:|:|:||..:|::|.:.:
  Rat   167 SPAIYVASQSVLSVYANGRVNGLVVDTGHGVSYTVPVFQGYNLPSGIQRMDLAGHYLTKFLAEKI 231

  Fly   203 LLRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQ-------RLALETTVLVESYTLPDGRVIKVG 260
            |...:|.. ..|.:|:..:|::.||:..|.:.||       |..|:         ||||::|.||
  Rat   232 LRSSFAVK-KEDMDTMENIKQQYCYVALDFQKEQGRPDEKFRRCLK---------LPDGQMITVG 286

  Fly   261 GERFEAPEALFQPHLINVEGP---GIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRL 322
            .|.|:.||.||.|.  :..||   |:..:..:::.....::|.::.::::|.|||:::.|...|.
  Rat   287 KELFQCPELLFHPP--DTSGPSSLGLPSMVEHSLSTVPQELRADMEQNVLLCGGSSLFTGFEGRF 349

  Fly   323 EREIKQLYLERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEV----TKDRDGFWMSKQEY 383
            :.|:    |.|:       ..:..:.:.....|...|:|||::||.:    |:     |:.:::|
  Rat   350 KTEL----LRRL-------GPEAHVVVVAQANRNLSVWIGGSILASLCAFQTR-----WVLREQY 398

  Fly   384 QEQGLKVLQKLQKIS 398
            :|.|..::  |:|.|
  Rat   399 EEHGPDIV--LRKCS 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	118/398 (30%)
Actl9b	NP_001013915.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		NBD_sugar-kinase_HSP70_actin	45..410	CDD:302596	119/402 (30%)
		Actin	47..411	CDD:278451	120/403 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910