DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and Actl6b

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_006249182.1	Gene:	Actl6b / 288563	RGDID:	1307763	Length:	444	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	129/463 - (27%)
Similarity:	203/463 - (43%)	Gaps:	113/463 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVCDNGTGFVKCGYAGSNFP------------------THIFPSMVGRPMIRAVNKIGDIEV--- 52
            :|.|.|:..|:.||||.:.|                  ...||:.||   :.|..:.|.:|:
  Rat    14 LVFDIGSFSVRAGYAGEDCPKVSLPVPSPYPRGSDTLCQADFPTTVG---LLAAEEGGGLELEGE 75

  Fly    53 -----KDLHVDD--LMVGDEASQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNT 110
                 |..|:|.  |.|..:.:      ||..|::||::.:|:....:.|:|:. |.:..:|...
  Rat    76 KEKKGKIFHIDTNALHVPRDGA------EVMSPLKNGMIEDWECFRAILDHTYS-KHVKSEPNLH 133

  Fly   111 KILLTEPPMNPTKNREKMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVY 175
            .:|::|.|.|....|||:.|:|||:|...:.::...||||.:|.|..:|:|:|||...|...||:
  Rat   134 PVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVH 198

  Fly   176 EEFALPHLTRRLDIAGRDITRYLIKLL------LLRGYAFNHSADFETVR-------IMKEKLCY 227
            :.:.|.....:..:||..|:....:|.      ::..|..   |..|.||       ..||||..
  Rat   199 DGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMI---AAKEPVREGAPPNWKKKEKLPQ 260

  Fly   228 IG--------------------------YDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEA 266
            :.                          ||   ||..|...||   .|.:|:|.....|.||...
  Rat   261 VSKSWHNYMCNEVIQDFQASVLQVSDSPYD---EQVAAQMPTV---HYEMPNGYNTDYGAERLRI 319

  Fly   267 PEALFQPHLINVEG------PGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLERE 325
            ||.||.|.  ||:|      .|:..:...:|...||||||.||..::::||:|:..|...||.||
  Rat   320 PEGLFDPS--NVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRE 382

  Fly   326 IKQ-----LYLERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQE 385
            :.|     :.|:.:..|.|.:             ||...:|||::||.:...:. .|:|||||:|
  Rat   383 LSQKTPPSMRLKLIASNSTME-------------RKFSPWIGGSILASLGTFQQ-MWISKQEYEE 433

  Fly   386 QGLKVLQK 393
            .|.:.:::
  Rat   434 GGKQCVER 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	129/461 (28%)
Actl6b	XP_006249182.1	Actin	11..444	CDD:394979	129/463 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910