DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and Actl7a

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_033741.1	Gene:	Actl7a / 11470	MGIID:	1343051	Length:	440	Species:	Mus musculus

Alignment Length:	395	Identity:	136/395 - (34%)
Similarity:	215/395 - (54%)	Gaps:	38/395 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKGR------NVIVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLM 61
            ||.|      ..:|.|.||||.|||:||...|||...:.||:|.:... |.||      :..:..
Mouse    65 SKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETA-KTGD------NRKETF 122

  Fly    62 VGDEASQLRSLLEVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNRE 126
            ||.|.......|::..|:.:|::.:||.:..:|:|.| .::|.|.|....:|:::||::|..|||
Mouse   123 VGHELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLF-RQEMKIAPEEHAVLVSDPPLSPHTNRE 186

  Fly   127 KMIEVMFEKYGFDSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAG 191
            |..|::||.:...:.:||.|:.|::|:.|..||:|::.|.||:::.|:||.:.||.:|.|||.||
Mouse   187 KYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAG 251

  Fly   192 RDITRYLIKLLLLRGYAFNHSADFETVRIMKEKLCYIGYD-IEMEQRLALETTVLVESYTLPDGR 255
            .|:|.||:.|:...|..|:.. ....|..:|.:.|::..| ||.::..|.|..:   .||||||:
Mouse   252 SDLTTYLMNLMNNSGKHFSED-HLGIVEDIKTRCCFVALDPIEEKKIPAPEHEI---HYTLPDGK 312

  Fly   256 VIKVGGERFEAPEALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPS 320
            .|::|.|||...|..|:|.||.....|:.....:.:...||.::.:|..:|:|.|||||..|.|:
Mouse   313 EIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPN 377

  Fly   321 RLEREIKQLYLERVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGF---WMSKQE 382
            ||::|     |..:..|||.       ::...|.|...|:.||::||.:    .||   |:.:.|
Mouse   378 RLQKE-----LSSMCPNDTP-------QVNVLPERDTAVWTGGSILASL----QGFQPLWVHRLE 426

  Fly   383 YQEQG 387
            |:|.|
Mouse   427 YEEHG 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	134/392 (34%)
Actl7a	NP_033741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		ACTL7A_N	6..70	CDD:293445	3/4 (75%)
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	133/388 (34%)
		ACTIN	74..440	CDD:214592	133/386 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810