DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and ACTL7A

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_006678.1	Gene:	ACTL7A / 10881	HGNCID:	161	Length:	435	Species:	Homo sapiens

Alignment Length:	383	Identity:	132/383 - (34%)
Similarity:	212/383 - (55%)	Gaps:	32/383 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSLL 73
            :|.|.|||:.|||:||...|||...:.||:|.:... |.||      :..:..||.|.:.....|
Human    72 VVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETA-KTGD------NRKETFVGQELNNTNVHL 129

  Fly    74 EVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYGF 138
            ::..|:.:|::.:||.:..:|:|.| .::|.|.|....:|:::||::|..||||..|::||.:..
Human   130 KLVNPLRHGIIVDWDTVQDIWEYLF-RQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFEAFNT 193

  Fly   139 DSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLLL 203
            .:.:||.|:.|::|:.|..||:|::.|.||:::.|:||.:.||.:|.|||.||.|:|.||:.||.
Human   194 PAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLLGLLN 258

  Fly   204 LRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLAL-ETTVLVESYTLPDGRVIKVGGERFEAP 267
            ..|..|... ....|..:|:|.|::..|...|:::.| |.|:   .|.||||:.|::..|||...
Human   259 SAGNEFTQD-QMGIVEDIKKKCCFVALDPIEEKKVPLSEHTI---RYVLPDGKEIQLCQERFLCS 319

  Fly   268 EALFQPHLINVEGPGIAELAFNTIQAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLE 332
            |..|:|.||.....|:.....:.:...||.::.:|..:|:|.|||||..|.|:||::|     |.
Human   320 EMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKE-----LS 379

  Fly   333 RVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGF---WMSKQEYQEQG 387
            .:..|||.       ::...|.|...|:.||::||.:    .||   |:.:.||:|.|
Human   380 SMCPNDTP-------QVNVLPERDSAVWTGGSILASL----QGFQPLWVHRFEYEEHG 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	132/383 (34%)
ACTL7A	NP_006678.1	ACTL7A_N	1..65	CDD:293445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		Required for interaction with TES	31..51
		NBD_sugar-kinase_HSP70_actin	67..435	CDD:302596	132/383 (34%)
		ACTIN	69..435	CDD:214592	132/383 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900