DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp2 and ACTL7B

DIOPT Version :9

Sequence 1:	NP_001259621.1	Gene:	Arp2 / 32623	FlyBaseID:	FBgn0011742	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_006677.1	Gene:	ACTL7B / 10880	HGNCID:	162	Length:	415	Species:	Homo sapiens

Alignment Length:	380	Identity:	133/380 - (35%)
Similarity:	208/380 - (54%)	Gaps:	25/380 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVCDNGTGFVKCGYAGSNFPTHIFPSMVGRPMIRAVNKIGDIEVKDLHVDDLMVGDEASQLRSLL 73
            ::.|.|:.:.||||||...||:...|.||:....|.: .||.....|      ||.|.....:.|
Human    52 VIIDLGSQYCKCGYAGEPRPTYFISSTVGKRCPEAAD-AGDTRKWTL------VGHELLNTEAPL 109

  Fly    74 EVSYPMENGVVRNWDDMCHVWDYTFGPKKMDIDPTNTKILLTEPPMNPTKNREKMIEVMFEKYGF 138
            ::..|:::|:|.:||.:..:|:|.| ...|.|.|....:|:::||::|:.||||..|:|||.:|.
Human   110 KLVNPLKHGIVVDWDCVQDIWEYIF-RTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGI 173

  Fly   139 DSAYIAIQAVLTLYAQGLISGVVIDSGDGVTHICPVYEEFALPHLTRRLDIAGRDITRYLIKLLL 203
            .:.::..|::|::|:.|..||:|::||.||:|:.|:.|...||.||.|.|.||.|:|.||::||.
Human   174 PAMHVTSQSLLSIYSYGKTSGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLN 238

  Fly   204 LRGYAFNHSADFETVRIMKEKLCYIGYDIEMEQRLALETTVLVESYTLPDGRVIKVGGERFEAPE 268
            ..|:||... ....:..:|:|.||..:  ..|:.|.|....|...|.||||::|.:|.|||...|
Human   239 EAGHAFTDD-HLHIIEHIKKKCCYAAF--LPEEELGLVPEELRVDYELPDGKLITIGQERFRCSE 300

  Fly   269 ALFQPHLINVEGPGIAELAFNTI-QAADIDIRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYLE 332
            .||||.|.....||:.||....: :..|...:.|:..:::|.||.||..|.|.|.:||:..|
Human   301 MLFQPSLAGSTQPGLPELTAACLGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLL--- 362

  Fly   333 RVLKNDTEKLAKFKIRIEDPPRRKDMVFIGGAVLAEVTKDRDGFWMSKQEYQEQG 387
              ...|:..:|.       .|.||..|:.||::||.:...:. .|:||:|::|:|
Human   363 --CPGDSPAVAA-------APERKTSVWTGGSILASLQAFQQ-LWVSKEEFEERG 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp2	NP_001259621.1	ACTIN	6..393	CDD:214592	133/380 (35%)
ACTL7B	NP_006677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
ACTL7B	NP_006677.1	NBD_sugar-kinase_HSP70_actin	51..415	CDD:327376	133/380 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900