Protein Alignment CG32669 and SLC5A2

DIOPT Version :10

• Sequence 1: NP_727460.1
• Gene: CG32669 / 326229
• FlyBaseID: FBgn0052669
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 134/589 - (22%)
• Similarity: 240/589 - (40%)
• Gaps: 133/589 - (22%)

  Fly     8 DYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTIL------ 66
            |..::|...::.:.:|: :......:.|...|.||.|||...||..||.||.:.:...:
Human    25 DILVIAAYFLLVIGVGL-WSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTG 88

  Fly    67 ---GVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLS 128
               |:::..:::..:|||:.|         .:|..||:......::.:||..||| ..|:...||
Human    89 AASGLAVAGFEWNALFVVLLL---------GWLFAPVYLTAGVITMPQYLRKRFG-GRRIRLYLS 143

  Fly   129 FSLQMVLY----MGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLL 189
            . |.:.||    :.:.:::.|:.::...|.:...|::.:..:...|...||:.|::.||..|:.:
Human   144 V-LSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFV 207

  Fly   190 MFAAVFSVIICAWVKAGSLEVIW----------RVAQENGRINLTNFSVDPTE------RH---- 234
            :......::..|:.:.|....::          .|:::....|:::|...|..      ||
Human   208 ILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTG 272

  Fly   235 --TWFTQILGGCATYLAIYGVNQTQVQRLMAVKSLSAARAALWWCLPILC-LLSLSTCF----SG 292
              .|...:||........:..:|..|||.:|.|||:..:|.   |  ||| .|.|:..|    .|
Human   273 DLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAG---C--ILCGYLKLTPMFLMVMPG 332

  Fly   293 LCIYWYYRD---------CDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTIS 348
            :.....|.|         |..:....|...:...|..||..|.  .||.||.::.:..|.:|:::
Human   333 MISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMP--NGLRGLMLAVMLAALMSSLA 395

  Fly   349 SIISSLAAV-TLEDY--LKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCIG-----MAFMAGSI 405
            ||.:|.:.: |::.|  |:|...        ||:.|...:|..:|...:.:.     .|...|.:
Human   396 SIFNSSSTLFTMDIYTRLRPRAG--------DRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQL 452

  Fly   406 GGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGA----IGGLLISLA-----FCFWIGFGQPK 461
            ...:||..|   .:..|:..:|.|.::|.:.||:||    |||||:.||     |.|  |.|...
Human   453 FDYIQAVSS---YLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSF--GSGSCV 512

  Fly   462 PPLVSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHYFYLYRISYMWYAALGFLITFFGGWLLSW 526
            .|        :.||.                       :|..:.|:::|    ::.||...||:.
Human   513 QP--------SACPA-----------------------FLCGVHYLYFA----IVLFFCSGLLTL 542

  Fly   527 LFAL 530
            ..:|
Human   543 TVSL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	133/584 (23%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	134/589 (23%)