Protein Alignment CG32669 and SLC5A1

DIOPT Version :10

• Sequence 1: NP_727460.1
• Gene: CG32669 / 326229
• FlyBaseID: FBgn0052669
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 150/679 - (22%)
• Similarity: 268/679 - (39%)
• Gaps: 157/679 - (23%)

  Fly     6 AWDYTILAVVLIISVAIGIYYRF------VGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVT 64
            |.|.:|:.:..::.:|:|::..|      |||       :.||.|||...|:..||.||.:.:..
Human    26 AADISIIVIYFVVVMAVGLWAMFSTNRGTVGG-------FFLAGRSMVWWPIGASLFASNIGSGH 83

  Fly    65 IL---------GVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYA 120
            .:         |:::..:::..:.:|:         |..:|.:|::.:....::.|||..||| .
Human    84 FVGLAGTGAASGIAIGGFEWNALVLVV---------VLGWLFVPIYIKAGVVTMPEYLRKRFG-G 138

  Fly   121 TRLAASLSFSLQMVLY----MGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLI 181
            .|:...||. |.::||    :...:::.|:.:....||:...:|.::..:...|...||:.||:.
Human   139 QRIQVYLSL-LSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIY 202

  Fly   182 TDIYQSLLMFAAVFSVIICAWVKAGSLEVIWR---------VAQEN---------GRINLTNFSV 228
            ||..|:::|......:...|:.:.|..:....         |:..|         .|.:..:...
Human   203 TDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFR 267

  Fly   229 DP-TERHTWFTQILGGCATYLAIYGVNQTQVQRLMAVKSLSAARAALWWCLPILC-LLSLSTCF- 290
            || |....|...|.|.....|..:..:|..|||.::.|::|..:..   |  ||| .|.|...|
Human   268 DPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGG---C--ILCGYLKLMPMFI 327

  Fly   291 ---SGLCIYWYY---------RDCDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCAS 343
               .|:.....|         .:|:.....:|...:...|..||:.|.  .||.||.:|.:..:.
Human   328 MVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMP--NGLRGLMLSVMLASL 390

  Fly   344 LSTISSIISSLAAV-TLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCIGMAF------M 401
            :|:::||.:|.:.: |::.|.|      .::..::::.:...:|..|    :.||::.      .
Human   391 MSSLTSIFNSASTLFTMDIYAK------VRKRASEKELMIAGRLFIL----VLIGISIAWVPIVQ 445

  Fly   402 AGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFC-------FWIGFGQ 459
            :...|.|.....||...:|.|:..:|.|.::..:.||.||..||::.|...       |..|.|.
Human   446 SAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGS 510

  Fly   460 PKPPLVSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHYFY----LYRISYMWYAALGFL---IT 517
            ...|        :.||            |:|...   ||.|    |:.||::....:..|   |.
Human   511 CMEP--------SNCP------------TIICGV---HYLYFAIILFAISFITIVVISLLTKPIP 552

  Fly   518 FFGGWLLSWLFALLKWDNNRRIYQDAD--------CTLIKHDLFVPPIAKRLQRRQMPLLVVTGT 574
            ....:.|.|   .|:.....||..||:        ...|:.:..||...|.:.||...|..
Human   553 DVHLYRLCW---SLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFC---- 610

  Fly   575 SSEIGGITTESATAPPRLDEIEWEKHKAV 603
                 |:....|   |::.|   |:.||:
Human   611 -----GLEQHGA---PKMTE---EEEKAM 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	129/592 (22%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	149/678 (22%)