DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32669 and Slc5a4a

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_573447.2	Gene:	Slc5a4a / 64452	MGIID:	1927848	Length:	656	Species:	Mus musculus

Alignment Length:	544	Identity:	125/544 - (22%)
Similarity:	238/544 - (43%)	Gaps:	90/544 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVSM 70
            |.|.:::.:..::.:|:|: :..:...:||...:.||.|||...|:..||.||.:.:...:|::.
Mouse    26 AADISVIVIYFVVVMAVGV-WAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAG 89

  Fly    71 ENYQYG---TMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLS---F 129
            .....|   |.|...:.:.:|   |..::.:|::.:....::.|||:.||| ..||...||   .
Mouse    90 TGAASGIAVTAFESHSFALLL---VLGWIFVPIYIKAGVMTMPEYLKKRFG-GKRLQIYLSILFL 150

  Fly   130 SLQMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAV 194
            .:.::|.:...:::.|:.::...||:...:|:|:..:...:...||:.:|:.||..|:::|....
Mouse   151 FICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGS 215

  Fly   195 FSVIICAWVKAGSLEVIWR---------VAQENGRINLTNFSVDPTERHTWFTQILG-----GCA 245
            |.:::.|:|:.|..|....         |..:|..||...::..|...|.:...:.|     |.|
Mouse   216 FILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTA 280

  Fly   246 -----TYLAIYGVNQTQVQRLMAVKSLSAARAALWWC-----LPILCLLSLSTCFSGLCIYWYYR 300
                 |.|..:.:||..|||.:..|:||..:||...|     ||:..::     ..|:.....|.
Mouse   281 FGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMV-----MPGMISRILYT 340

  Fly   301 D---------CDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAA 356
            |         |.......|...:...|:.|:..|.  .||.||.:|.:..:.:|:::|:.:|.:.
Mouse   341 DMVACVVPSECVKHCGVDVGCTNYAYPMLVLKLMP--MGLRGLMLSVMLASLMSSLTSVFNSAST 403

  Fly   357 V-TLEDYLKPLVSCCAKRTLTDRQTLWYSKL-LSLFFGALCIGMAFMAGSIGG-LLQAALSIFGI 418
            : |::.|.|      .::..::|:.|...:| :|:......:.:..:..|.|| |:....:|...
Mouse   404 LFTIDLYTK------IRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSY 462

  Fly   419 IGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFC-------FWIGFGQPKPPLVSLDMSTAGCPV 476
            :|.|:..:|.:.::..:|||:||..||::.|...       |..|.|....|        :.||
Mouse   463 LGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYGTGSCLAP--------SSCP- 518

  Fly   477 DRSFARDIFLKTVIAVAEEEHYFY 500
                      |.:..|    ||.|
Mouse   519 ----------KIICGV----HYLY 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	124/543 (23%)
Slc5a4a	NP_573447.2	SLC5-6-like_sbd	27..656	CDD:294310	124/543 (23%)
Slc5a4a	NP_573447.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810