DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32669 and slc5a12

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	618	Identity:	231/618 - (37%)
Similarity:	347/618 - (56%)	Gaps:	55/618 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATLG---AWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSA 62
            |.|:|   |.||.:.|.:.::|..||:::......::.:.|:|:..|.|:..|||.||.||||||
Zfish     1 METVGRFQAGDYVVFACLFVVSSGIGVFFAIKERNKAPSKEFLVGGRQMSCGPVALSLTASFMSA 65

  Fly    63 VTILGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASL 127
            ||::|...:.|::|..:|:..::|.......|.|.:|||||....|.||||||||....|:||:|
Zfish    66 VTVIGAPADVYRFGASYVIFGVAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCKLVRVAATL 130

  Fly   128 SFSLQMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFA 192
            .:.:|.:||.|:|||||||||..|||.....||...|:|||||.||||:|||:.||.:|.::|..
Zfish   131 IYIIQTILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTFYCTLGGLKAVVWTDAFQMVVMVV 195

  Fly   193 AVFSVIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQ 257
            ...:|:|....:||.:|.:|..::..||:.:.:|.|.|..|||::|..:||..|:|.||||||:.
Zfish   196 GFLTVLIQGSSRAGGIENVWSTSRTGGRLQVFDFDVSPLRRHTFWTLSVGGTFTWLGIYGVNQST 260

  Fly   258 VQRLMAVKSLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVV 322
            :||.::.|:...||.||:..|..|.::......|||.:|.||..|||...|.:::.||:||.||:
Zfish   261 IQRCISCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLISAPDQLMPYFVM 325

  Fly   323 DTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLL 387
            :.:|.:.||.||||:..|..:|||:::.|::||.|..||:    ||.|.. .|::|...|.||.|
Zfish   326 EILGAFPGLPGLFVACAFSGTLSTVAASINALATVMYEDF----VSQCFP-DLSNRAASWISKAL 385

  Fly   388 SLFFGALCIGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFC 452
            .:.||..|..||..|..:||::||||||.|:.|||:||||:||:.....|.|||:|||::.::..
Zfish   386 CVAFGVACTTMAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGGLIVGISLS 450

  Fly   453 FWIGFG-----QPKPPLVSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHYF--YLYRISYMWYA 510
            ||:|.|     .|.....:|:::||||.:..: |.:....||..:..:.::.  ..|.:||::|:
Zfish   451 FWVGVGAFIYPAPSNNTHALELNTAGCNITAA-AFEPTSATVTQLTSDRNWLADSWYSMSYLYYS 514

  Fly   511 ALGFLITFFGGWLLSWLFALLKWDNNRRIYQDADCTLIKHDLFVPPIAKRLQRRQMPLLVVTGTS 575
            |:||:.|...|.|::                          |...|:..:|.:..|     |.:.
Zfish   515 AVGFIGTVAAGLLIT--------------------------LLTGPMDPKLLKPGM-----TRSV 548

  Fly   576 SEIGGITTESATAPPRLDEIE--------WEKH 600
            .|:....||..|.....:..|        ||||
Zfish   549 KEVMCFCTEKFTEADLGEGKEDVGDFGKAWEKH 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	213/526 (40%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	216/560 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm6386
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870