DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32669 and RGD1563815

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006256382.1	Gene:	RGD1563815 / 365549	RGDID:	1563815	Length:	695	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	132/635 - (20%)
Similarity:	241/635 - (37%)	Gaps:	167/635 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATLG-----AWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMAS--- 58
            :|||     ..|..::...|::.:.||: :..:...:.|..::.||.:::....:..|:.:|
  Rat    15 STLGLSIHSTVDTLVMTFYLLLVLCIGL-WALLSHSRGTIKDFFLAGQNLAWWLMGLSIYSSTVG 78

  Fly    59 ---FMSAVTI---LGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRF 117
               ||....|   .|:::..:::.|:|::..|.::         .:|::.:....::.|||:.||
  Rat    79 SGHFMGLAGIGAASGIAVGAFEWNTVFMLFMLGWI---------FVPIYSKAGVVTLPEYLKKRF 134

  Fly   118 GYATRLAASLSFSLQMVLYMGIV---VYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAV 179
            | :.|:....||...:|..:..:   :...|:.|:.|..:....:::.|..:...|...||:..|
  Rat   135 G-SVRIQLFFSFVFLIVYILSRISMEIGFGAMFLKMVWDIDIYQTMLTVLTITGVYTITGGLATV 198

  Fly   180 LITDIYQ--------SLLMFAAVFSVIICAWVKAGSLEVIWRVAQE-NGRINLTNFSVDP---TE 232
            ...:..|        :|||..|.:.|       .|..|::.:.::. ...|...|::..|   |.
  Rat   199 AYVETLQAGIMVLGSALLMGYAFYEV-------GGYQELVNKYSKAIPSTIQQGNWTAKPECYTP 256

  Fly   233 R----HTWFTQILG---------GCATYLAIYG-VNQTQVQRLMAVKSLSAARAALWWC-----L 278
            |    |.:.:.:.|         |..|....|| .:|..|||.:|.||..........|     |
  Rat   257 REDAFHVFRSCVSGDVPWPGLVLGATTVSLFYGCADQVSVQRFLAGKSRLHMEGGCLLCGYLKLL 321

  Fly   279 PILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQV----------------------MPLFV 321
            |:..::.                  |.:..||...|||                      .|:.|
  Rat   322 PMFLMVM------------------PGMISRVLFPDQVACVVPSECEKFCGRGTGCSALAYPVLV 368

  Fly   322 VDTMGEYTGLAGLFVSGIFCASL-STISSIISSLAAV-TLEDY--LKPLVSCCAKRTLTDRQTLW 382
            :..|.  :||.|..:|.: |||| |:::||.:|.:|: ||..|  ::|        |.|:::.:
  Rat   369 LGVMP--SGLQGFMLSTV-CASLMSSLTSIFNSSSALFTLNIYTWIRP--------TATEKELM- 421

  Fly   383 YSKLLSLFFGALCIGMAF-------MAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKG 440
               :...||..:.:.:..       ||.| ..|.:....:...:...:..:|.|.::..:.||:|
  Rat   422 ---IAGRFFVIILLAVTIVWIPIIEMAPS-ETLFEYMQILKSCLTPSVTAVFLLAVFCKRVNEQG 482

  Fly   441 AIGGLLIS-------LAFCFWIGFGQPKPPLVSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHY 498
            |..||::.       |...|:.|     ||....|..   ||        ||:..:       ||
  Rat   483 AFWGLILGSTIGVFRLLAEFFYG-----PPTCGEDRQ---CP--------IFICGL-------HY 524

  Fly   499 FY----LYRISYMWYAALGFLITFFGGWLLSWLFALLKWDNNRRIYQDAD 544
            .|    |..:|.:...|:...........|..|...|:....||:..|.|
  Rat   525 LYFGFCLLLVSILIILAISLATEPIADDHLHGLCWSLRNSQQRRVALDKD 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	123/606 (20%)
RGD1563815	XP_006256382.1	SLC5-6-like_sbd	26..695	CDD:294310	129/624 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810