DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32669 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001102058.1	Gene:	Slc5a12 / 362188	RGDID:	1311652	Length:	619	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	220/550 - (40%)
Similarity:	327/550 - (59%)	Gaps:	23/550 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVSM 70
            ||||.:.|.:.:||..||:::.....|::|:.|:|:..|.|:.||||.||.||||||||:||...
  Rat     8 AWDYVVFAALFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFAPVALSLTASFMSAVTVLGTPA 72

  Fly    71 ENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSLQMVL 135
            |.|::|..|::..:||.......:.|.:|||||....|.||||:|||....|.||::.:.||.:|
  Rat    73 EVYRFGASFLIFLISYAFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYILQTIL 137

  Fly   136 YMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFSVIIC 200
            |.|:|||||||||..|||.:...|:...|:|||||.:|||:|||:.||.:|.::|.....:|:|.
  Rat   138 YTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVLIQ 202

  Fly   201 AWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRLMAVK 265
            .....|..:.:...|:...|:::.:|.|||..|||::|..:||..|:|.||||||:.:||.::.|
  Rat   203 GSNHVGGFDNVLEQARNGSRLDIVDFDVDPLRRHTFWTIAVGGTFTWLGIYGVNQSTIQRCISCK 267

  Fly   266 SLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMGEYTG 330
            :...|:.||::.|..|.::.:...|.||.:|.||:||||...|.:.:.||:||.||::......|
  Rat   268 TEKHAKLALYFNLLGLWIIVVCAVFCGLIMYAYYKDCDPWTSGAILAPDQLMPYFVMEIFATMPG 332

  Fly   331 LAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALC 395
            |.||||:..|..:|||:::.|::||.||.||::|   ||...  |:|..:.|.||.|.|.||.:|
  Rat   333 LPGLFVACAFSGTLSTVAASINALATVTFEDFVK---SCFPH--LSDTLSTWISKGLCLLFGIIC 392

  Fly   396 IGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWIGFG-- 458
            ..||.:|..:|.::||||||.|:.|||:|||||||:.....|.|||:||||..:...||:|.|
  Rat   393 TSMAVLASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFPFVNWKGALGGLLTGITLSFWVGIGAF 457

  Fly   459 ---QPKPPLVSLDMSTAGCPVDRSFARDIF-LKTVIAVAEEEHYFYLYRISYMWYAALGFLITFF 519
               .|....:.|.:||..|........:.: |.:...:|:.     .|.:||::::|:|.|....
  Rat   458 VYPAPDSKTLPLPLSTEFCVQQNKTTTEAYQLSSRPVLADT-----WYSLSYLYFSAVGCLGCIA 517

  Fly   520 GGWLLSWLFALLKWDNNRRIYQDADCTLIK 549
            .|.::|:|       ..|:..:|.|..||:
  Rat   518 AGIIISFL-------TGRQRGKDVDPLLIR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	213/525 (41%)
Slc5a12	NP_001102058.1	SLC5sbd_SMCT2	3..527	CDD:212089	215/535 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770