DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32669 and Slc5a4b

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_008771154.1	Gene:	Slc5a4b / 294342	RGDID:	1309867	Length:	660	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	131/599 - (21%)
Similarity:	246/599 - (41%)	Gaps:	108/599 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVSM 70
            |.|.:::.:..::.:|:|: :..|...:.|...:.||.|.::..|:..||.||.:.:...:|::.
  Rat    26 AADISVIVIYFLVVLAVGL-WSMVRSNRGTIGGFFLAGRDVSWWPMGASLFASNIGSNHFVGLAG 89

  Fly    71 ENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRL---AASLSFSLQ 132
            .....|.....:..:.:|...|..::.:|::.:....::.|||..||| ..||   .:.||..:.
  Rat    90 TGAASGIAIAAVEWNALLMVLVLGWVFVPIYIKAGVTTMPEYLRKRFG-GKRLQIYLSVLSLFIM 153

  Fly   133 MVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFSV 197
            :.:.....:::.|:.::...||:...::.|:..:..||...||:.:|:.||..|:.:|......:
  Rat   154 VAIQTSSTIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLVGSLIL 218

  Fly   198 IICAWVKAGSLEVIWR---------VAQENGRINLTNFSVDPTERH----------TWFTQILGG 243
            :..|:.:.|..|....         |..:|..|:...::..|...|          .|...|.|
  Rat   219 MGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHIFRDPINGDIPWPGLIFG- 282

  Fly   244 CATYLAI--YGVNQTQVQRLMAVKSLSAARAALWWC-----LPILCLLSLSTCFSGLCIYWYYRD 301
             .|.|||  :..:|..|||.:..|::|..:||...|     ||:..::     ..|:.....|.|
  Rat   283 -MTILAIWYWCADQVMVQRCLCGKNMSHVKAACIMCGYLKLLPMFLMV-----MPGMISRILYTD 341

  Fly   302 ---------CDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAV 357
                     |.......|...:...|..|::.|.:  ||.||.:|.:..:.:|:::||.:|.:.:
  Rat   342 KVACVVPSECVKQCGTAVGCTNYAYPTLVLELMPD--GLRGLMLSVMLASLMSSLTSIFNSASTL 404

  Fly   358 -TLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCIGMAFM------AGSIGGLLQAALSI 415
             |::.|.|      .::..::|:.:...::    ||.:.|.::.:      |...|.|.....|.
  Rat   405 FTMDLYTK------IRKKASERELMVAGRV----FGIVLIVISILWVPLIQASQNGQLFHYISSF 459

  Fly   416 FGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFC-------FWIGFGQPKPPLVSLDMSTAG 473
            ...||.|:..:|.|.::..:.||:||..||::.|...       |..|.|....|        :.
  Rat   460 SSYIGPPVGAVFLLAIFCKRVNEQGAFWGLMVGLVIGLIRMITEFIYGTGSCLEP--------SN 516

  Fly   474 CPVDRSFARDIFLKTVIAVAEEEHYFY----LYRISYMWYAALGFL---ITFFGGWLLSWLFALL 531
            ||           :.:..|    ||.|    |:.:|.:....:.||   |.....:.|.|..
  Rat   517 CP-----------RIICGV----HYMYFAIILFFVSILVILGVSFLTEPIPDVHLYRLCWSL--- 563

  Fly   532 KWDN-NRRIYQDAD 544
             |:| ..||..||:
  Rat   564 -WNNTEERIDLDAE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	123/578 (21%)
Slc5a4b	XP_008771154.1	SLC5-6-like_sbd	27..660	CDD:294310	130/598 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810