DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32669 and SLC5A12

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_848593.2	Gene:	SLC5A12 / 159963	HGNCID:	28750	Length:	618	Species:	Homo sapiens

Alignment Length:	534	Identity:	213/534 - (39%)
Similarity:	317/534 - (59%)	Gaps:	34/534 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVSME 71
            |||.:.|.:..||..||:::.....|::|:.|:|:..|.|:..||..||.||||||||:||...|
Human     9 WDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSE 73

  Fly    72 NYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSLQMVLY 136
            .|::|..|:|..::|:....:.:.|.:|||||....|.||||:|||....|.||::.:.:|.:||
Human    74 VYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIYIVQTILY 138

  Fly   137 MGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFSVIICA 201
            .|:|||||||||..|||.....|:...|:|||||.||||:|||:.||.:|.::|.....:|:|..
Human   139 TGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQG 203

  Fly   202 WVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRLMAVKS 266
            ...||....:...:....|:::.:|.|||..|||::|..:||..|:|.||||||:.:||.::.|:
Human   204 STHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKT 268

  Fly   267 LSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMGEYTGL 331
            ...|:.||::.|..|.::.:...||||.:|.:::||||...|.:::.||:||.||::......||
Human   269 EKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPDQLMPYFVMEIFATMPGL 333

  Fly   332 AGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCI 396
            .||||:..|..:|||::|.|::||.||.||::|   ||...  |:|:.:.|.||.|.|.||.:|.
Human   334 PGLFVACAFSGTLSTVASSINALATVTFEDFVK---SCFPH--LSDKLSTWISKGLCLLFGVMCT 393

  Fly   397 GMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWIGFG--- 458
            .||..|..:||::||:|||.|:.|||:||||:||:.....|.|||:||||..:...||:..|
Human   394 SMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIGAFI 458

  Fly   459 QPKP-------PL-----VSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHYFYLYRISYMWYAA 511
            .|.|       ||     :..:::..|.||         |.:...:|:.     .|.|||::|:|
Human   459 YPAPASKTWPLPLSTDQCIKSNVTATGPPV---------LSSRPGIADT-----WYSISYLYYSA 509

  Fly   512 LGFLITFFGGWLLS 525
            :|.|.....|.::|
Human   510 VGCLGCIVAGVIIS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	213/534 (40%)
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	213/534 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I905
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1707
Isobase	1	0.950	-	0	Normalized mean entropy	S4392
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm8669
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.750