DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32669 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	221/607 - (36%)
Similarity:	327/607 - (53%)	Gaps:	69/607 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATLGAWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTIL 66
            ||.|||||.:.|.:|::|..||::.....|.|.:..::....|.:...||..||.|||||||.:|
  Rat    10 ATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVL 74

  Fly    67 GVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSL 131
            ||..|..:||..|:.:....:|::.:.|:|.:|:||||...|.|:||||||..|.||..:|.:.:
  Rat    75 GVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLV 139

  Fly   132 QMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFS 196
            ..:||.|||:|||||.|..||||....|::..|::||.|.|:||||||:.||::|.::|....:.
  Rat   140 ATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWV 204

  Fly   197 VIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRL 261
            ::....:..|....:..:||.:.||||.:|..||..|:|::|.|:||...:|::|||||.||||.
  Rat   205 ILARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRY 269

  Fly   262 MAVKSLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMG 326
            :|..:...|:.||......|.|:..|....|:.::.||:||||||.||:::.||.|||.|:|...
  Rat   270 VACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFE 334

  Fly   327 EYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFF 391
            :..|:.|||::..:..:|||.|:.|:::||||:||.:||.:...|.|.|     ::.||.||..:
  Rat   335 DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKL-----VFISKGLSFIY 394

  Fly   392 GALCIGMAFMAGSI-GGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWI 455
            |:.|:.:|.::..: ||:||.:.::.|:|.|||||.|||||.:...|..|.:.||...||...|:
  Rat   395 GSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWV 459

  Fly   456 GFGQP-KPP----LVSLDMSTAGCPVD------------------------RSFARDIFLKTVIA 491
            ..|.. .||    :..|..|.|||..|                        |....|.|
  Rat   460 AVGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTF------ 518

  Fly   492 VAEEEHYFYLYRISYMWYAALGFLITFFGGWLLSWLF----------ALLKWDNNRRIYQDA--- 543
                      |.|||::|.|||.|.|...|.|:|:|.          .||.||..|:....|
  Rat   519 ----------YAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKE 573

  Fly   544 -----DCTLIKHDLFVPPIAKR 560
                 :.:|:|....:|.:.|:
  Rat   574 DTATLEESLVKGPEDIPAVTKK 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	206/549 (38%)
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	207/554 (37%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870