DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32669 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus

Alignment Length:	594	Identity:	217/594 - (36%)
Similarity:	325/594 - (54%)	Gaps:	56/594 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATLGAWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTIL 66
            ||.|.|||.:.|.:|::|..||::.....|.|.:..::....|.:...||..||.|||||||.:|
Mouse    10 ATFGPWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVL 74

  Fly    67 GVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSL 131
            ||..|..:||..|:.:.:..:|::.:.|.|.:|:||||...|.|:||||||..|.||..:|.:.:
Mouse    75 GVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLV 139

  Fly   132 QMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFS 196
            ..:||.|||:|||||.|..||||....|::..|::||.|.|:||||||:.||::|.::|....:.
Mouse   140 ATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWV 204

  Fly   197 VIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRL 261
            ::....:..|....:..:||.:.||||.:|..||..|:|::|.::||...:|::|||||.||||.
Mouse   205 ILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQAQVQRY 269

  Fly   262 MAVKSLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMG 326
            :|..:...|:.||......|.|:..|....|:.::.||:||||||.||:.:.||.|||.|:|...
Mouse   270 VACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLVLDIFE 334

  Fly   327 EYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFF 391
            :..|:.|||::..:..:|||.|:.|:::||||:||.:||.:.     :|..|:.::.||.||..:
Mouse   335 DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMP-----SLAPRKLVFISKGLSFIY 394

  Fly   392 GALCIGMAFMAGSI-GGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWI 455
            |:.|:.:|.::..: ||:||.:.::.|:|.|||||.|||||.:...|..|.:.||...||...|:
Mouse   395 GSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLTAGLAVSLWV 459

  Fly   456 GFGQP-KPP----LVSLDMSTAGC---------PVDRSFARDI-----------FLKTVIAVAEE 495
            ..|.. .||    :..|..|.|||         |...:.:|.|           |..|
Mouse   460 AVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMDSGRPAFADT------- 517

  Fly   496 EHYFYLYRISYMWYAALGFLITFFGGWLLSWLF----------ALLKWDNNRR---IYQDADCTL 547
                 .|.:||::|.|||.|.|...|.|:|:|.          .||.||..|:   :....|.|.
Mouse   518 -----FYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTTT 577

  Fly   548 IKHDLFVPP 556
            ::..|...|
Mouse   578 LEDSLVKGP 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	204/545 (37%)
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	205/550 (37%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	366	1.000	Domainoid score	I922
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm8902
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870