DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32669 and slc5a7

DIOPT Version :9

Sequence 1:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_002937709.1	Gene:	slc5a7 / 100490609	XenbaseID:	XB-GENE-961535	Length:	580	Species:	Xenopus tropicalis

Alignment Length:	614	Identity:	129/614 - (21%)
Similarity:	234/614 - (38%)	Gaps:	117/614 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VAIGIYY---RFVG-----------GKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTILGVSM 70
            |||.::|   .|||           |........::..|.:.:...||::.|:::....|.|.:.
Frog     9 VAIILFYLAILFVGIWAAWRTKNSRGDGDPREGIIVGGRDIGLLVGAFTMTATWVGGGYINGTAE 73

  Fly    71 ENY--QYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSLQM 133
            ..|  .||..:....:.|.||..|..     :|:.....|.        ||.|.|.     ..|.
Frog    74 AVYVSDYGLAWAQAPIGYSLSLIVGG-----LFFAKPMRSK--------GYVTMLD-----PFQQ 120

  Fly   134 VL--YMGIVVYAPAL----------------ALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVL 180
            :.  .||.:::.|||                .:..:..:....|:|:..::.|||..:||:.:|.
Frog   121 IYGKRMGGLLFIPALMGEMFWAAAILSALGATISVIVDIDINISVVVSALIATFYTLVGGLYSVA 185

  Fly   181 ITDIYQSLLMFAAVFSVIICAWVKAGSLEVIWRVAQENGRI-NLTNFSVDPTERHTWFTQILGGC 244
            .||:.|       :|.:.|..|:..       ..|..:..: ::|..:|....:..|...|....
Frog   186 YTDVVQ-------LFCIFIGLWISV-------PFAMTHPAVTDITVTAVKEVYQKPWLGDIRAAD 236

  Fly   245 A-------TYLAIYGVN-QTQVQRLMAVKSLSAARA----ALWWCLPILCLLSLSTCFSGLCIYW 297
            |       ..|.:.|:. |...||:::..|.:.|:.    |.:.|| ::.:.|:.....|....|
Frog   237 AWNWLDSFLLLMLGGIPWQAYFQRVLSASSATYAQVLSFLAAFGCL-VMAIPSVLIGAIGASTDW 300

  Fly   298 ---YYRDCDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTL 359
               .|...||.:.   ...|.::|:.:......|....||  ..:..|.:|:..|.|.|.:::
Frog   301 NQTSYEHDDPQMN---EEADMILPIVLQYLCPPYISFFGL--GAVSAAVMSSADSSILSASSM-- 358

  Fly   360 EDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCIGMAFMAGSIGGLLQAALSIFGIIGGPLL 424
              :.:.:.....::..::::.:|..::....|||....||.:|.|:.||...:..:..||..|.|
Frog   359 --FARNIYQLSFRQNASEKEIVWVMRITVFIFGAAATAMALLAKSVYGLWYLSSDLVYIIIFPQL 421

  Fly   425 GLFTLGMYVTKANEKGAIGGLLISLAFCFWIGFGQPKPPLVSLDMSTAGCPVDRSFARDIFL--- 486
               ...:::...|..|::.|.:...  ...|..|:|...|.:. :...||..|::   |::|
Frog   422 ---LCVLFIKGTNTYGSVAGYVFGA--LLRISGGEPYLHLQAF-ICYPGCYADKN---DMYLQRF 477

  Fly   487 --KTVIAVAEEEHYFYLYRISYMWYAALGFLITFFGGWLLSWLFALLKWDNNRRIYQDAD-CTLI 548
              ||:..||.     :|..|::.:.|..     .|...:||..|..|.....:...::.| .||:
Frog   478 PFKTLSMVAS-----FLANIAFSYLARY-----LFEKGILSPKFDFLNAVVAKHSEENMDKTTLV 532

  Fly   549 KHDLFVPPIAKRLQRRQMPLLVVTGTSSE 577
            |.|..|......::.||...|..|.|:.|
Frog   533 KSDNIVLSELAPVKPRQSLSLPSTFTNKE 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	115/561 (20%)
slc5a7	XP_002937709.1	SLC5sbd_CHT	8..495	CDD:271368	111/541 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910