DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32647 and DGCR2

DIOPT Version :9

Sequence 1:	NP_001285168.1	Gene:	CG32647 / 326226	FlyBaseID:	FBgn0052647	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_005128.1	Gene:	DGCR2 / 9993	HGNCID:	2845	Length:	550	Species:	Homo sapiens

Alignment Length:	232	Identity:	55/232 - (23%)
Similarity:	87/232 - (37%)	Gaps:	59/232 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QTTWRRQRGCCTTTTTAAIRNMQQQKQKQQQQS------------YLQRLKAAGRL--GAWPPPM 87
            ||..|......|.:|...:|.:..|:..|.::|            |...:....|.  |.|....
Human   143 QTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAF 207

  Fly    88 --TSLLWLPTDYLAQLILA-----LCL-LGCL---------------------SPFTAALEEDCV 123
              :|.::||.|.:....::     .|. |.|.                     |.|.....:.||
Human   208 KGSSEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQTCV 272

  Fly   124 DFQGNKVNHGMLYVP-GPGVCSLCVCYHSEPLWCKAIYCDPPYFCKNFRVG-ERCCEFECLDPPG 186
            |.:.|.|:.|..:.| |...|..|.|:..||..|.|..|:.|..|:.:|.. :.||:|.||||.|
Human   273 DIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDPDG 337

  Fly   187 EDKLYQERMRKRAEILAGNSTASNVQLAPIAMSTIML 223
             :.|:             :|.||.::|....:|:.::
Human   338 -NSLF-------------DSMASGMRLVVSCISSFLI 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32647	NP_001285168.1	VWC	130..178	CDD:302663	16/49 (33%)
DGCR2	NP_005128.1	LDLa	30..66	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..92
		CLECT_DGCR2_like	115..267	CDD:153069	22/123 (18%)
		VWC	271..329	CDD:214564	20/57 (35%)
		Atrophin-1	<428..537	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140858
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15256
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5741
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	4.020