DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and HEPH

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_620074.3	Gene:	HEPH / 9843	HGNCID:	4866	Length:	1212	Species:	Homo sapiens

Alignment Length:	686	Identity:	129/686 - (18%)
Similarity:	192/686 - (27%)	Gaps:	293/686 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVQTLVFTLCLISVQIYG--------------------IQDASGKRIVSKYERIMQ--------- 40
            :.|||.:.|.|::|...|                    :...|...:::|....|:
Human     1 MTQTLPYHLSLLNVLFPGPCSRHFKFRRGKCAQPAWRKVSAPSQDLLITKVMWAMESGHLLWALL 65

  Fly    41 ----MYPQLSSGAG-------ESSQWRAAEKDNQRHPCRRDCADKQPMTCYYYMVVHYDDTMAET 94
                ::|||:.||.       ...||..|.|.       |:....||:.         .|.:|.:
Human    66 FMQSLWPQLTDGATRVYYLGIRDVQWNYAPKG-------RNVITNQPLD---------SDIVASS 114

  Fly    95 CKRYLQSKFRFKLSGKEYIDGIALATQLAANDDCKYADGLESEVMVVNGQL-PGMNIEVCYGDTV 158
                      |..|.|..|.|....|......|..|.|.:.....:  |.| |.:..||  ||.:
Human   115 ----------FLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWL--GFLGPVLQAEV--GDVI 165

  Fly   159 VADVINSMHETTTIHWHGMHQR------LTP--------FMDGVP----HVTQYPIEAGQAFRYR 205
            :..:.|......|||.||:...      |.|        ..|.||    |:..:.|..|.|   .
Human   166 LIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHA---P 227

  Fly   206 FEVDHGGTNW-WHSHTEHQR--AFGLAGPLVV--------RMPPKLNPHAHLYDFDMSEHVIMIQ 259
            .:.|.....| :|||.:..|  |.||.|||:.        ..||:.                  |
Human   228 TDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQR------------------Q 274

  Fly   260 DWVHNFVESVAENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNGVSNCPISFSID 324
            |..|:|.      :|.:....||.                       :.:..|..:.|....|:|
Human   275 DVDHDFF------LLFSVVDENLS-----------------------WHLNENIATYCSDPASVD 310

  Fly   325 KHDLVVIASD-------------------------------GNDIEPVEVQRIMFHGAERFDFVL 358
            |.|.....|:                               ||:|   :|....|||........
Human   311 KEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEI---DVHTAFFHGQMLTTRGH 372

  Fly   359 HANQEVSNY-----------------WI-----------------RVKGYSFCAKNQLHQEAVLH 389
            |.  :|:|.                 |:                 :||..|......|....|..
Human   373 HT--DVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQ 435

  Fly   390 YRDADTRALDTHTLSYAY------DAPGKTLNELGD------DASGARAGNSISLANLNAQRPEP 442
            |      .::.|.:.:.|      .:.||.|.|.|.      ..|.:|.|.:
Human   436 Y------FIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGT------------- 481

  Fly   443 EVAPSVTFYTSMNAFEVRQGEGFRFQMDDISFSMPKMSLLQTRNLGVGQFFCNRSQQADLGFNCR 507
                    |..:. :|..|.|.|:          .||.|.:.|:||:            ||
Human   482 --------YWKVR-YEAFQDETFQ----------EKMHLEEDRHLGI------------LG---- 511

  Fly   508 QRHCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHG 543
                   .||:......::.|..:.:..|..:..||
Human   512 -------PVIRAEVGDTIQVVFYNRASQPFSMQPHG 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	97/519 (19%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	35/132 (27%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	30/201 (15%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	14/76 (18%)
HEPH	NP_620074.3	CuRO_1_ceruloplasmin	80..262	CDD:259884	52/214 (24%)
		CuRO_2_ceruloplasmin	277..417	CDD:259907	23/173 (13%)
		CuRO_3_ceruloplasmin	431..626	CDD:259886	31/171 (18%)
		CuRO_4_ceruloplasmin	629..772	CDD:259908
		CuRO_5_ceruloplasmin	787..959	CDD:259887
		Cupredoxin	974..1117	CDD:302766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.110