DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and FET3

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_013774.1	Gene:	FET3 / 855080	SGDID:	S000004662	Length:	636	Species:	Saccharomyces cerevisiae

Alignment Length:	526	Identity:	130/526 - (24%)
Similarity:	222/526 - (42%)	Gaps:	90/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 DCKYADGLESE-VMVVNGQLPGMNIEVCYGDTVVADVINSMHET-TTIHWHGMHQRLTPFMDGVP 189
            |.:..|||:|. |:..|||.|..:|.|..||.|...:.|.|:.| |::|:||:.|..|..|||||
Yeast    33 DYRNVDGLKSRPVITCNGQFPWPDITVNKGDRVQIYLTNGMNNTNTSMHFHGLFQNGTASMDGVP 97

  Fly   190 HVTQYPIEAGQAFRYRFEVDHG-GTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDFDMSE 253
            .:||.||..|....|.|.||:. ||.|:||||:.|...|:.|..:::      ..:..||:| .|
Yeast    98 FLTQCPIAPGSTMLYNFTVDYNVGTYWYHSHTDGQYEDGMKGLFIIK------DDSFPYDYD-EE 155

  Fly   254 HVIMIQDWVHNFV----------------ESVAENILINGRGRNLKKGVKAAKPTLYAHFPVVRG 302
            ..:.:.:|.|:.|                |.:.:|:::|.              |:...:.|...
Yeast   156 LSLSLSEWYHDLVTDLTKSFMSVYNPTGAEPIPQNLIVNN--------------TMNLTWEVQPD 206

  Fly   303 GRYRFRVIFNG--VSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVS 365
            ..|..|::..|  ||.   .|.|:.|::.|:..||...|......:....|:|:..::|...:..
Yeast   207 TTYLLRIVNVGGFVSQ---YFWIEDHEMTVVEIDGITTEKNVTDMLYITVAQRYTVLVHTKNDTD 268

  Fly   366 NYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSI 430
                  |.::...|   ..:.:|....:|.:...|..:.|...|...|.|.:          :||
Yeast   269 ------KNFAIMQK---FDDTMLDVIPSDLQLNATSYMVYNKTAALPTQNYV----------DSI 314

  Fly   431 S--LANLNAQRPEPEV---APSVTFYTSMNAFEVRQGEGFRFQMDDISFSMPKMSLLQTRNLGVG 490
            .  |.:...|..|.|.   .|.......:....::.|..:.| .::|:::.||:..|.|
Yeast   315 DNFLDDFYLQPYEKEAIYGEPDHVITVDVVMDNLKNGVNYAF-FNNITYTAPKVPTLMT------ 372

  Fly   491 QFFCNRSQQADLGFNCRQRHCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMGVLG 555
              ..:...||    |..:.:...::...:..::.||.|:::.....||.||||:.|:.:......
Yeast   373 --VLSSGDQA----NNSEIYGSNTHTFILEKDEIVEIVLNNQDTGTHPFHLHGHAFQTIQRDRTY 431

  Fly   556 EQKIGQIEQI---DKKTPLPRRAKGAPL-KDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSEN 616
            :..:|::...   |.....|.    .|: :|::.|......::||.:::||.|.|||||..|...
Yeast   432 DDALGEVPHSFDPDNHPAFPE----YPMRRDTLYVRPQSNFVIRFKADNPGVWFFHCHIEWHLLQ 492

  Fly   617 GMAAVV 622
            |:..|:
Yeast   493 GLGLVL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	129/521 (25%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	47/105 (45%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	27/154 (18%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	37/159 (23%)
FET3	NP_013774.1	SufI	7..489	CDD:225043	127/515 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343589
Domainoid	1	1.000	91	1.000	Domainoid score	I1742
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I948
Isobase	1	0.950	-	0	Normalized mean entropy	S12213
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm9215
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X253
TreeFam	1	0.960	-	-
	12	11.700