DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and sks5

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_177743.1	Gene:	sks5 / 843948	AraportID:	AT1G76160	Length:	541	Species:	Arabidopsis thaliana

Alignment Length:	567	Identity:	122/567 - (21%)
Similarity:	210/567 - (37%)	Gaps:	127/567 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 GIALATQLAAND-------DCKYAD----GLESEVMVVNGQLPGMNIEVCYGDTVVADVINSMHE 168
            |::|...:.|.|       :..|.|    |:..:.:::||..||.:|.....|.::.:|.||:.|
plant    14 GLSLLFAVTAEDPYRFFEWNITYGDIYPLGVRQQGILINGAFPGPDIHSVTNDNLIINVYNSLDE 78

  Fly   169 TTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAFRYRFEVDH--GGTNWWHSHTEHQRAFGLAGP 231
            ...:.|:|:.||...|:||| :.|..||..|:.:.|..::..  |...::.|...|:.|.|..|.
plant    79 PFLLSWNGIQQRRNSFVDGV-YGTTCPIPPGKNYTYILQMKDQIGSFYYFPSLGFHKAAGGFGGI 142

  Fly   232 LVVRMP----PKLNPHAHLYDFDMSEHVIMIQDWV---HNFVESVAEN---------ILINGRGR 280
            .::..|    |..:|        ..:..::|.||.   |..:.:..:|         ||||||..
plant   143 RILSRPRIPVPFPDP--------AGDTTVLIGDWYKANHTDLRAQLDNGKKLPLPDGILINGRSS 199

  Fly   281 NLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQR 345
            .             |...|.:|..||||:...|:.: .::|.|..|.:.|:..:|..........
plant   200 G-------------ATLNVEQGKTYRFRISNVGLQD-SLNFRIQDHKMKVVEVEGTHTLQTTFSS 250

  Fly   346 IMFHGAERFDFVLHANQEVSNYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALDTHTLSYAYDAP 410
            :..|..:.:..::.|:|...:|::.|.  |....|.|....:..|.::        ....:...|
plant   251 LDVHVGQSYSVLVTADQTPRDYYVVVS--SRFTSNVLTTTGIFRYSNS--------AGGVSGPIP 305

  Fly   411 GKTLNELGDDASGARAGNSISLANLNAQRPEPEVAPSVTFYTSM--------NAFEVRQGEG-FR 466
            |....::....:.|||..:    ||:|..|.|.  |..:::..|        .|....|.:| .|
plant   306 GGPTIQIDWSLNQARAIRT----NLSASGPRPN--PQGSYHYGMINTTRTIRLASSAGQVDGKQR 364

  Fly   467 FQMDDISFSMPKMSL----------------LQTRNLGVGQFFCNRSQQADLGFNCRQRHCQCSN 515
            :.::.:||......|                :|.:..|.|.:.                   .::
plant   365 YAVNSVSFKPADTPLKIADYFKIDGVYRSGSIQYQPTGGGIYL-------------------DTS 410

  Fly   516 VIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPR---RAKG 577
            |:||.....||.:..:........||.||:|.||||.  |.|          .:|..|   ..:.
plant   411 VMQVDYRTFVEIIFENSEDIVQSWHLDGYSFWVVGMD--GGQ----------WSPDSRNEYNLRD 463

  Fly   578 APLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSENGMAAVVRV 624
            |..:.:|||....:|.:....::.|.|............|....:||
plant   464 AVARCTVQVYPSSWTAILIALDNVGMWNLRSEFWARQYLGQQLYLRV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	117/543 (22%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	31/108 (29%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	32/148 (22%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	34/176 (19%)
sks5	NP_177743.1	PLN02991	10..541	CDD:215536	122/567 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880