DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and sks12

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_175953.1	Gene:	sks12 / 842006	AraportID:	AT1G55570	Length:	555	Species:	Arabidopsis thaliana

Alignment Length:	525	Identity:	125/525 - (23%)
Similarity:	206/525 - (39%)	Gaps:	103/525 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GLESEVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIE 197
            |:..:|:::|||.||.||.....:.|:.:|.|::.|...|.|.|:..|...:.||... |..||.
plant    44 GVPQQVILINGQFPGPNINSTSNNNVIVNVFNNLDEPFLITWAGIQHRKNCWQDGTAG-TMCPIP 107

  Fly   198 AGQAFRYRFE-VDHGGTNWWHSHTEHQRAFGLAGPLVVR----MP-PKLNPHAHLYDFDMSEHVI 256
            .||.|.|.|: .|..|:.:::..|...||.|..|.|.|.    :| |..:|.        .::.|
plant   108 PGQNFTYHFQPKDQIGSYFYYPTTAMHRAAGGFGGLRVNSRLLIPVPYADPE--------DDYTI 164

  Fly   257 MIQDW-------VHNFVES-----VAENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRV 309
            :|.||       :..|::|     ..:.|||||:.   .|...:.||.    |.:..|..||.|:
plant   165 LINDWYTKSHTQLKKFLDSGRTIGRPDGILINGKS---GKTDGSDKPL----FTLKPGKTYRVRI 222

  Fly   310 IFNGVSNCPISFSIDKHDLVVIASDG-----NDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWI 369
            ...|: ...::|.|..|.:.::..:|     ||.:.::|     |..:.|..::.|:||..:|::
plant   223 CNVGL-KASLNFRIQNHKMKLVEMEGSHVLQNDYDSLDV-----HVGQCFGVIVTADQEPKDYYM 281

  Fly   370 RVKGYSFCAKNQLHQEAVLHYRDADTRA---LDTHTLSYAYDAPGKTLNELGDDASGARAGNSIS 431
             :....| .|..|....:|.|......|   |....:.:|:     :||:.........|
plant   282 -IASTRF-LKKPLTTTGLLRYEGGKGPASSQLPAAPVGWAW-----SLNQYRSFRWNLTA----- 334

  Fly   432 LANLNAQRPEPEVAPSVTFYTSMNAFEV-----RQGE---GFRFQMDDISFSMPKMSLLQTRNLG 488
                :|.||.|:   ....|..:|....     .||:   ..|:.:..:|.:.|:..|......|
plant   335 ----SAARPNPQ---GSYHYGKINITRTIKLVNTQGKVDGKLRYALSGVSHTDPETPLKLAEYFG 392

  Fly   489 VGQFFCNRSQQADLGFNCRQRHCQCS-NVIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMG 552
            |..........:|.....:.::.:.. ||:.:.....:|.|..:..::....||.||:|..|.
plant   393 VADKVFKYDTISDNPNPDQIKNIKIEPNVLNITHRTFIEVVFENHERSVQSWHLDGYSFFAVA-- 455

  Fly   553 VLGEQKIGQIEQIDKKTPLPRRAKGAPLKD-----SVQV-PAFGYTILRFYSNSPGYWMFHCHIS 611
                        ::..|..|.:.|...|.|     :||| |.....||..:.|. |.|      :
plant   456 ------------VEPGTWTPEKRKNYNLLDAVSRHTVQVYPKCWAAILLTFDNC-GMW------N 501

  Fly   612 PHSEN 616
            ..|||
plant   502 IRSEN 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	125/525 (24%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	35/102 (34%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	37/153 (24%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	33/156 (21%)
sks12	NP_175953.1	PLN02354	2..554	CDD:177987	125/525 (24%)
		CuRO_1_AAO_like_1	31..146	CDD:259915	35/102 (34%)
		CuRO_2_AAO_like_1	160..300	CDD:259940	37/154 (24%)
		CuRO_3_AAO_like_1	381..506	CDD:259961	30/145 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.960