DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and LAC1

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_173252.2	Gene:	LAC1 / 838393	AraportID:	AT1G18140	Length:	581	Species:	Arabidopsis thaliana

Alignment Length:	607	Identity:	150/607 - (24%)
Similarity:	245/607 - (40%)	Gaps:	140/607 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 AETCKRYLQSKFRFKLSGKEYIDGIALATQLAANDDCKYADGLESEVMVVNGQLPGMNIEVCYGD 156
            |.|.:|     |.|.:..|:       .|:|...          .:::.||||.||..:.|..||
plant    25 ASTTRR-----FHFNVEWKK-------VTRLCHT----------KQLLTVNGQYPGPTVAVHEGD 67

  Fly   157 TVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAFRYRFEV-DHGGTNWWHSHT 220
            .|...|.|.:...|||||||:.|..|.:.||..::||.||.:.|::.|||:| |..||..||:|.
plant    68 IVEIKVTNRIAHNTTIHWHGLRQYRTGWADGPAYITQCPIRSKQSYTYRFKVEDQRGTLLWHAHH 132

  Fly   221 EHQRAFGLAGPLVV--RMPPKLNPHAHLYDFD----MSEHVIMIQDWVHNFVESVAENILINGRG 279
            ..||| .:.|..::  |.|         |.|.    .||..|::.:|.::.|::|.:.::..|.|
plant   133 SWQRA-SVYGAFIIYPRQP---------YPFSGSHIQSEIPIILGEWWNDDVDNVEKAMMKTGAG 187

  Fly   280 RNLKKGVK-----------AAKPTLYAHFPVVRGGRYRFRVIFNGVSNCPISFSIDKHDLVVIAS 333
            ..:.....           :.|.|..|  .|..|..|..|:| |...|..:..::..|.|.|:..
plant   188 AKVSDAYTLNGLPGPLYPCSTKDTFTA--TVDAGKTYILRII-NAALNNELFVAVANHTLTVVEV 249

  Fly   334 DGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFCAKNQLHQEAVLHYRDADTRAL 398
            |....:||..:.||....:....:|.|:|        :.|..|......:..:|..:.::.|...
plant   250 DAVYTKPVHTKAIMIAPGQTTTLLLRADQ--------LSGGEFLIAATPYVTSVFPFNNSTTVGF 306

  Fly   399 DTHTLSYAYDAPGKTLNELGDDASGAR----AGNSISLANL-----------------NAQRP-- 440
            ..:|        |||..|...:....|    ....::|.|:                 :|:.|
plant   307 IRYT--------GKTKPENSVNTRRRRRLTAMSTVVALPNMLDTKFATKFSDSIKSLGSAKYPCK 363

  Fly   441 -EPEVAPSVTFYTSMNAFE--VRQ------GEGFRFQMDDISFSMPKMSLLQT--RNLGVGQFFC 494
             ..::...|....|:|..:  :.|      |:.|...|::|||..|.:|:|::  :....|.|..
plant   364 VPTKIDKRVITTISLNLQDCPLNQTCDGYAGKRFFASMNNISFVRPPISILESYYKKQSKGVFSL 428

  Fly   495 -------NR---------SQQADLGFNCRQRHCQCSNVIQVPANQQVEFVI---SSLSQTPHPIH 540
                   ||         |:..:..|.        :.:.:|....::|.|.   |.|:...||:|
plant   429 DFPEKPPNRFDFTGVDPVSENMNTEFG--------TKLFEVEFGSRLEIVFQGTSFLNIENHPLH 485

  Fly   541 LHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYWM 605
            :||:.|.|||.|      .|..:  .:|.|........|.:::..||..|:..:|..:::||.|.
plant   486 VHGHNFFVVGRG------FGNFD--PEKDPKRYNLVDPPERNTFAVPTGGWAAIRINADNPGVWF 542

  Fly   606 FHCHISPHSENGMAA--VVRVG 625
            .|||:..|:..|:|.  :|:.|
plant   543 IHCHLEQHTSWGLAMGFIVKDG 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	142/567 (25%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	42/105 (40%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	31/147 (21%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	47/181 (26%)
LAC1	NP_173252.2	laccase	28..581	CDD:274556	148/604 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930