DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and sks17

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_569041.1	Gene:	sks17 / 836826	AraportID:	AT5G66920	Length:	546	Species:	Arabidopsis thaliana

Alignment Length:	539	Identity:	125/539 - (23%)
Similarity:	217/539 - (40%)	Gaps:	82/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GLESEVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIE 197
            |:..:|:::|||.||..:||...|.::.::||.:.:...:.|:|:.||...:.|||.. |..||:
plant    52 GVPQQVILINGQFPGPKLEVVTNDNIILNLINKLDQPFLLTWNGIKQRKNSWQDGVLG-TNCPIQ 115

  Fly   198 AGQAFRYRFEV-DHGGT-NWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDFDMSEHVIMIQD 260
            ....|.|:|:. |..|| |::.|...|:.|.|.....|...|....|    |....::..:::.|
plant   116 PNSNFTYKFQTKDQIGTFNYFPSTAFHKAAGGFGAINVYARPGIPIP----YPLPTADFTLLVGD 176

  Fly   261 WV---HNFVES---------VAENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNG 313
            |.   |..::.         ..:.:||||:.::...|              .:|..|..|:...|
plant   177 WFKTNHKTLQQRLDSGGVLPFPDGMLINGQTQSTFSG--------------DQGKTYMLRISNVG 227

  Fly   314 VSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFCA 378
            :|: ..:|.|..|.:.|:..:|:.:...:...:..|..:....::..||...:|:| |....| .
plant   228 LSS-TFNFRIQGHTMKVVEVEGSHVIQTDYDSLDIHVGQSLAVLVTLNQSPKDYYI-VASTRF-I 289

  Fly   379 KNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSISLANL--NAQRPE 441
            :::|....:|.|.::...|        :.|.|.....||......||...    .||  ||.||.
plant   290 RSKLSVMGLLRYSNSRVPA--------SGDPPALPPGELVWSMRQARTFR----WNLTANAARPN 342

  Fly   442 PE-------VAPSVTFYTSMNAFEVRQGEGFRFQMDDISFSMPKMSLLQTRNLGV-GQFFCNRSQ 498
            |:       ::|:.||..| |:..:..|:. |:.::.:|:...:..|....:.|: |.|..|..|
plant   343 PQGSFHYGMISPTKTFVFS-NSAPLINGKQ-RYAVNGVSYVKSETPLKLADHFGISGVFSTNAIQ 405

  Fly   499 QADLGFNCRQRHCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIE 563
            ...    ........::|:|...:..:|.|..:..::....||.||.|.|||.|      .||
plant   406 SVP----SNSPPTVATSVVQTSHHDFLEIVFQNNEKSMQSWHLDGYDFWVVGFG------SGQ-- 458

  Fly   564 QIDKKTPLPRRAKG---APLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSENGMAAVVRVG 625
                .||..|....   |..:.:.||....:|.:....::.|.|.....|.....:|....::|.
plant   459 ----WTPAKRSLHNLVDALTRHTTQVYPESWTTILVSLDNQGMWNMRSAIWERQYSGQQFYLKVW 519

  Fly   626 EDVEM---KMCPVSNCGLC 641
            ..|:.   :..|..|..||
plant   520 NSVQSLANEYNPPDNLQLC 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	120/519 (23%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	34/103 (33%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	27/148 (18%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	35/171 (20%)
sks17	NP_569041.1	PLN02835	28..546	CDD:178429	125/539 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880