DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and LAC16

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001330402.1	Gene:	LAC16 / 836008	AraportID:	AT5G58910	Length:	567	Species:	Arabidopsis thaliana

Alignment Length:	548	Identity:	145/548 - (26%)
Similarity:	232/548 - (42%)	Gaps:	89/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 VMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAF 202
            ::.||||.||..|....|||::..|:|.:....:|||||:.|..|.:.||..::||.||:.||.:
plant    50 IVTVNGQFPGPTIVAREGDTILIKVVNHVKYNVSIHWHGIRQLRTGWADGPAYITQCPIQPGQNY 114

  Fly   203 RYRFEV-DHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLN---PHAHLYDFDMSEHVIMIQDWVH 263
            .:.|.: ...||.|||:|....|| .:.|.:|:.  |||.   |....|    .|..|::.:|..
plant   115 LHNFTLTGQRGTLWWHAHILWLRA-TVHGAIVIL--PKLGVPYPFPKPY----KEKTIVLSEWWK 172

  Fly   264 NFVE-------------SVAENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNGVS 315
            :.||             |.::...|||...::.   .....:.|. .||..|..|..|:| |...
plant   173 SDVEELINEASRIGTAPSASDAHTINGHSGSIS---NCPSQSSYG-LPVRAGKTYMLRII-NAAL 232

  Fly   316 NCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEV-SNYWIRVKGY--SFC 377
            |..:.|.|..|.|.|:..|....:|.:...:.....:..:.:|.||... |||.:....:  :..
plant   233 NEELFFKIAGHVLTVVEVDAVYTKPYKTDTVFIAPGQTTNVLLTANANAGSNYMVAATTFTDAHI 297

  Fly   378 AKNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSISLANLNA----Q 438
            ..:.:...|.||| ...|..:.|...:.....|.:       :|:......:.||.:||:    .
plant   298 PYDNVTATATLHY-IGHTSTVSTSKKTVLASLPPQ-------NATWVATKFTRSLRSLNSLEYPA 354

  Fly   439 RPEPEVAPSVTFYTSMNAFEVRQ-GEGFRF--QMDDISFSMPKMSLLQTRNLGVGQFFC------ 494
            |....|..|:.|...:.|...:. ..|.|.  .:::::|:|||.:|||.....:...|.
plant   355 RVPTTVEHSLFFTVGLGANPCQSCNNGVRLVAGINNVTFTMPKTALLQAHFFNISGVFTDDFPAK 419

  Fly   495 -----NRSQQADLGFNCRQRHCQCSNVIQVPANQQVEFVISS----LSQTPHPIHLHGYTFRVVG 550
                 :.:....||.|...  .:.:.:.::|.|..|:.|:.:    ||.. ||.||||:.|..||
plant   420 PSNPYDYTAPVKLGVNAAT--MKGTKLYRLPYNATVQIVLQNTAMILSDN-HPFHLHGFNFFEVG 481

  Fly   551 MGVLGE-------QKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYWMFHC 608
            .| ||.       :....::.:::.|              |.|||.|:|.:||.:::||.|..||
plant   482 RG-LGNFNPEKDPKAFNLVDPVERNT--------------VGVPAGGWTAIRFIADNPGVWFMHC 531

  Fly   609 HISPHSENG--MAAVVRVGEDVEMKMCP 634
            |:..|:..|  ||.||..|...:..:.|
plant   532 HLELHTTWGLKMAFVVDNGHGPDQSLLP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	143/538 (27%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	38/97 (39%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	33/152 (22%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	51/188 (27%)
LAC16	NP_001330402.1	laccase	28..567	CDD:274556	145/548 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930