DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and TT10

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_199621.2	Gene:	TT10 / 834862	AraportID:	AT5G48100	Length:	565	Species:	Arabidopsis thaliana

Alignment Length:	544	Identity:	151/544 - (27%)
Similarity:	237/544 - (43%)	Gaps:	77/544 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 VMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAF 202
            ::.||.|.||..|:|..|||:..:|.|...|..|:||||:.|...|:.||..::||.||..|..|
plant    42 ILTVNSQFPGPIIKVHKGDTIYVNVQNRASENITMHWHGVEQPRNPWSDGPEYITQCPIRPGSDF 106

  Fly   203 RYR--FEVDHGGTNWWHSHTEHQRA--FGLAGPLVVRMPPKLNPHAHLYDFDMSEH--VIMIQDW 261
            .|:  |.:: ..|.|||:|:...||  .||.  .|...||::.|      |..::|  .|::.:|
plant   107 LYKVIFSIE-DTTVWWHAHSSWTRATVHGLI--FVYPRPPQILP------FPKADHEVPIILGEW 162

  Fly   262 VHNFVESVAENILINGRGRNLKKG--VKAAKPTLYA-------HFPVVRGGRYRFRVIFNGVSNC 317
            ....|..|.|..:..|...|:...  :......||.       |..|.:|..||.|:: |...|.
plant   163 WKRDVREVVEEFVRTGGAPNVSDALTINGHPGFLYPCSKSDTFHLTVEKGKTYRIRMV-NAAMNL 226

  Fly   318 PISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVS-NYWIRVKGYSFCAKNQ 381
            |:.|:|..|.|.|:::||:.|:|::...|.....|..|.:|||:|:.. .|::..:.|
plant   227 PLFFAIANHSLTVVSADGHYIKPIKATYITISPGETLDMLLHADQDPERTYYMAARAY------- 284

  Fly   382 LHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELG--------DDASGARAGNSISLANLNAQ 438
              |...:.:.::.|..:    |||......||.:..|        :|.|.|....:......:.|
plant   285 --QSGNIDFNNSTTIGI----LSYTSSCKAKTSSFSGYYPTLPFYNDTSAAFGFFTKIKCLFSGQ 343

  Fly   439 RP---EPEVAPSVTFYTSM---NAFEVRQGEGFRFQMDDISFSMPK-MSLLQTRNLGVGQFFCNR 496
            .|   ...:..:|:....|   |:.|...|......|::|||..|. :.:|:.....:...:..|
plant   344 VPVQISRRIITTVSINLRMCPQNSCEGPNGSRLAASMNNISFVTPSHVDILKAYYYHIKGVYGTR 408

  Fly   497 SQQ-ADLGFNCRQRHCQ--------CSNVIQVPANQQVEFVISSLSQT----PHPIHLHGYTFRV 548
            ..: ..|.||....:..        .:.|..:...|.||.||...|..    .||:||||::|.|
plant   409 FPEFPPLIFNFTAENQPLFLETPRLATEVKVIEFGQVVELVIQGTSLVGGGLDHPMHLHGFSFYV 473

  Fly   549 VGMGVLGEQKIGQIEQIDKKTPLPR-RAKGAPLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISP 612
            ||:| .|...|.:      :.|..| .....|.|:::.||..|:..:||.:::||.|..|||:..
plant   474 VGVG-FGNYNISE------EDPSSRYNLYDPPYKNTMTVPRNGWIAIRFVADNPGVWFMHCHLDR 531

  Fly   613 HSENGMAAV--VRVGEDVEMKMCP 634
            |...||..|  |:.|.:...::.|
plant   532 HQTWGMNVVFIVKNGREPNQQILP 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	149/534 (28%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	40/100 (40%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	38/148 (26%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	51/181 (28%)
TT10	NP_199621.2	laccase	19..553	CDD:274556	150/540 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	1	1.010	-	-		QHG58299
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.940