DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and AT5G21105

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_680176.5	Gene:	AT5G21105 / 832235	AraportID:	AT5G21105	Length:	588	Species:	Arabidopsis thaliana

Alignment Length:	578	Identity:	159/578 - (27%)
Similarity:	249/578 - (43%)	Gaps:	116/578 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 DCKYADGLESEVMVVNGQLPGMNIEVCYGDTVVADVINSM-HETTTIHWHGMHQRLTPFMDGVPH 190
            |||     |..||.|||:.||..|:...|||:|.::.|.: .|...|||||:.|..:|:.||...
plant    52 DCK-----EGAVMTVNGEFPGPTIKAFAGDTIVVNLTNKLTTEGLVIHWHGIRQFGSPWADGAAG 111

  Fly   191 VTQYPIEAGQAFRYRFEVDHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDFDMSEHV 255
            |||..|..|:.|.|.|.|:..||:::|.|...||:.||.|.|:|.: .|.......||   .|..
plant   112 VTQCAINPGETFTYNFTVEKPGTHFYHGHYGMQRSAGLYGSLIVDV-AKGKSERLRYD---GEFN 172

  Fly   256 IMIQDWVHNFVES--------------VAENILINGRGR------------------NLKKGVKA 288
            :::.||.|..:.|              .|::|||||||:                  ..|:|.:.
plant   173 LLLSDWWHEAIPSQELGLSSKPMRWIGEAQSILINGRGQFNCSLAAQFSNNTSLPMCTFKEGDQC 237

  Fly   289 AKPTLYAHFPVVRGGRYRFRVIFNGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAER 353
            |...|:    |.....||.| :.:..:...::.::..|.|||:.:|||.|.|.....|..:..|.
plant   238 APQILH----VEPNKTYRIR-LSSTTALASLNLAVQGHKLVVVEADGNYITPFTTDDIDIYSGES 297

  Fly   354 FDFVLHANQEVS-NYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNEL 417
            :..:|..:|:.| ||:|.| |......|......:|:|..|....|.:        :| ..:...
plant   298 YSVLLTTDQDPSQNYYISV-GVRGRKPNTTQALTILNYVTAPASKLPS--------SP-PPVTPR 352

  Fly   418 GDDASGARAGNSISLANLNAQRPEPEVAPSVTFYTSMNAFEVRQGEGF-RFQMDDISFSMPKMSL 481
            .||...::..:....:.:.:..|..:....:....:.|..     :|: ::.::::|...|
plant   353 WDDFERSKNFSKKIFSAMGSPSPPKKYRKRLILLNTQNLI-----DGYTKWAINNVSLVTP---- 408

  Fly   482 LQTRNLGVGQFFCNRSQQADLGFNCRQ-----------------RHCQCSNVIQV-PANQQVEFV 528
             .|..||..::      ...||||.:.                 .:....|.|.| |.|..|:.:
plant   409 -ATPYLGSVKY------NLKLGFNRKSPPRSYRMDYDIMNPPPFPNTTTGNGIYVFPFNVTVDVI 466

  Fly   529 ISS------LSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVP 587
            |.:      :....||.||||:.|.|:|.|. |:.|.|    ||:||   ...|..||:::..:.
plant   467 IQNANVLKGIVSEIHPWHLHGHDFWVLGYGD-GKFKPG----IDEKT---YNLKNPPLRNTAILY 523

  Fly   588 AFGYTILRFYSNSPGYWMFHCHISPHSENGMAAVV-----RVGEDVEMKMCPVSNCGL 640
            .:|:|.:||.:::||.|.|||||.||...||..|.     |:|:..:..:    .|||
plant   524 PYGWTAIRFVTDNPGVWFFHCHIEPHLHMGMGVVFAEGLNRIGKVPDEAL----GCGL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	152/557 (27%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	43/103 (42%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	42/169 (25%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	55/193 (28%)
AT5G21105	NP_680176.5	PLN02191	15..588	CDD:177843	159/578 (28%)
		Cupredoxin	38..157	CDD:302766	47/109 (43%)
		Cupredoxin	168..334	CDD:302766	43/174 (25%)
		CuRO_3_AAO	381..569	CDD:259960	57/211 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	120	1.000	Domainoid score	I1881
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58299
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.790