DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and LAC8

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_195724.1	Gene:	LAC8 / 831877	AraportID:	AT5G01040	Length:	584	Species:	Arabidopsis thaliana

Alignment Length:	582	Identity:	157/582 - (26%)
Similarity:	237/582 - (40%)	Gaps:	124/582 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 CKYADGLESEVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVT 192
            ||     |..:...||.|||..|.|..|||:|.:|||:.....||||||:.|..:.:|||...:|
plant    43 CK-----EQIIPAANGSLPGPTINVREGDTLVVNVINNSTYNVTIHWHGVFQLKSVWMDGANMIT 102

  Fly   193 QYPIEAGQAFRYRFEV-DHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDF--DMSEH 254
            |.||:.|..|.|:|:: ...||..||:|..:.|| .|.|.||:| |....|    |.|  ...|.
plant   103 QCPIQPGYNFTYQFDITGQEGTLLWHAHVVNLRA-TLHGALVIR-PRSGRP----YPFPKPYKEV 161

  Fly   255 VIMIQDWVHNFVE-------SVAENILING-----------RGRNLKKGVKAAKPTLYAHFPVVR 301
            .|:.|.|....|.       .|::..||||           |..|||               ||:
plant   162 PIVFQQWWDTDVRLLQLRPAPVSDAYLINGLAGDSYPCSENRMFNLK---------------VVQ 211

  Fly   302 GGRYRFRVIFNGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSN 366
            |..|..|:: |...|..:.|.|..|::.|:|.|.....|.....::....:..|.:|.|:|.:..
plant   212 GKTYLLRIV-NAALNTHLFFKIANHNVTVVAVDAVYSTPYLTDVMILTPGQTVDALLTADQAIGK 275

  Fly   367 YWIRVKGYSFCAKNQLHQEAVLHYRDA---------DTRALDTHTLSYAYDAPGKTLNELGDDAS 422
            |::                |.|.|..|         .||.|..:..:.:..:|.:.|..:.:|.|
plant   276 YYM----------------ATLPYISAIGIPTPDIKPTRGLIVYQGATSSSSPAEPLMPVPNDMS 324

  Fly   423 GAR--AGNSISLANLNAQRPEPEVAPSVTFYTSMNAFEV---------RQGEGFRFQMDDISFSM 476
            .|.  ..|..||.......|.|.......|.|.....:.         ..|:.:...:::.:|.:
plant   325 TAHRFTSNITSLVGGPHWTPVPRHVDEKMFITMGLGLDPCPAGTKCIGPLGQRYAGSLNNRTFMI 389

  Fly   477 PKMSLLQTRNLGVGQFFCNRS--------QQADLGFNCRQRHCQCSN------------VIQVPA 521
            |:...:|.      .:|.|.|        .|..|.|:..:...:.:|            |.::..
plant   390 PERISMQE------AYFYNISGIYTDDFPNQPPLKFDYTKFEQRTNNDMKMMFPERKTSVKKIRF 448

  Fly   522 NQQVEFVISS---LSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLKDS 583
            |..||.|:.:   :|...||:||||:.|.|:|.|......|....:::...|        .:.::
plant   449 NSTVEIVLQNTAIISPESHPMHLHGFNFYVLGYGFGNYDPIRDARKLNLFNP--------QMHNT 505

  Fly   584 VQVPAFGYTILRFYSNSPGYWMFHCHISPHSENGM--AAVVRVGEDVEMKM-CPVSNCGLCS 642
            |.||..|:.:|||.:|:||.|:||||:..|...|:  |.:|:.|...|..: .|.||...|:
plant   506 VGVPPGGWVVLRFIANNPGVWLFHCHMDAHLPYGIMSAFIVQNGPTPETSLPSPPSNLPQCT 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	149/559 (27%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	44/103 (43%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	35/154 (23%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	49/190 (26%)
LAC8	NP_195724.1	laccase	25..566	CDD:274556	156/579 (27%)
		CuRO_1_LCC_plant	30..146	CDD:259918	47/109 (43%)
		CuRO_2_LCC_plant	161..303	CDD:259943	39/173 (23%)
		CuRO_3_LCC_plant	406..549	CDD:259964	41/150 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930