DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and AT5G01050

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_195725.1	Gene:	AT5G01050 / 831812	AraportID:	AT5G01050	Length:	586	Species:	Arabidopsis thaliana

Alignment Length:	584	Identity:	151/584 - (25%)
Similarity:	231/584 - (39%)	Gaps:	126/584 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 CKYADGLESEVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVT 192
            ||     |..:.:|||.|||..|.|..|||:|..|||......||||||:.|..:.:|||...:|
plant    43 CK-----EQMIPIVNGSLPGPTINVREGDTLVVHVINKSTYNVTIHWHGVFQLKSVWMDGANMIT 102

  Fly   193 QYPIEAGQAFRYRFEV-DHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDF--DMSEH 254
            |.||:....|.|:|:: ...||..||:|..:.|| .:.|.|::| |....|    |.|  ...|.
plant   103 QCPIQPSNNFTYQFDITGQEGTLLWHAHVVNLRA-TIHGALIIR-PRSGRP----YPFPKPYKEV 161

  Fly   255 VIMIQDWVHNFVE-------SVAENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFN 312
            .::.|.|....|.       .|::..||||...:   ....:|..:: :..||:|..|..|:| |
plant   162 PLIFQQWWDTDVRLLELRPAPVSDAYLINGLAGD---SYPCSKNRMF-NLKVVQGKTYLLRII-N 221

  Fly   313 GVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFC 377
            ...|..:.|.|..|::.|:|.|.....|.....::....:..|.:|.|:|.:..|::
plant   222 AALNTHLFFKIANHNVTVVAVDAVYTTPYLTDVMILTPGQTIDAILTADQPIGTYYM-------- 278

  Fly   378 AKNQLHQEAVLHYRDA----------DTRALDTHTLSYAYDAPGKTLNELGDDASGAR--AGNSI 430
                    |::.|..|          .||.|..:..:.:..:|.|......:|...|.  :.|..
plant   279 --------AIIPYFSAIGVPASPDTKPTRGLIVYEGATSSSSPTKPWMPPANDIPTAHRFSSNIT 335

  Fly   431 SLANLNAQRPEP------------------------------EVAPSVTFYTSMNAFEVRQGEGF 465
            ||.......|.|                              .:|.|:...|.|....:...|.:
plant   336 SLVGGPHWTPVPRHVDEKMFITMGLGLDPCPSNAKCVGPLDQRLAGSLNNRTFMIPERISMQEAY 400

  Fly   466 RFQM-----DD------ISFSMPKMSLLQTRNLGVGQFFCNRSQQADLGFNCRQRHCQCSNVIQV 519
            .:.:     ||      :.|...|.....| |..:...|..|.                ::|..:
plant   401 FYNITGVYTDDFPDQPPLKFDFTKFEQHPT-NSDMEMMFPERK----------------TSVKTI 448

  Fly   520 PANQQVEFVISS---LSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLK 581
            ..|..||.|:.:   |:...||:||||:.|.|:|.|......|....:::...|        .:.
plant   449 RFNSTVEIVLQNTGILTPESHPMHLHGFNFYVLGYGFGNYDPIRDARKLNLFNP--------QMH 505

  Fly   582 DSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSENG--MAAVVRVGEDVEMKM-CPVSNCGLCS 642
            ::|.||..|:.:|||.:|:||.|:||||:..|...|  ||.:|:.|...|..: .|.||...|:
plant   506 NTVGVPPGGWVVLRFIANNPGIWLFHCHMDAHLPLGIMMAFIVQNGPTRETSLPSPPSNLPQCT 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	143/561 (25%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	42/103 (41%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	31/143 (22%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	48/181 (27%)
AT5G01050	NP_195725.1	laccase	25..568	CDD:274556	150/581 (26%)
		CuRO_1_LCC_plant	30..146	CDD:259918	45/109 (41%)
		CuRO_2_LCC_plant	161..304	CDD:259943	35/163 (21%)
		CuRO_3_LCC_plant	407..551	CDD:259964	46/168 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930