DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and LAC10

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_195739.2	Gene:	LAC10 / 831697	AraportID:	AT5G01190	Length:	558	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	137/555 - (24%)
Similarity:	227/555 - (40%)	Gaps:	105/555 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 EVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQA 201
            :::.|||:.||..|.....||::.:|:|::....:|||||:.|..|.:.||..::||.||:.|.:
plant    44 QIVTVNGKFPGPTIYANEDDTILVNVVNNVKYNVSIHWHGIRQLRTGWADGPAYITQCPIKPGHS 108

  Fly   202 FRYRFEV-DHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLN-----PHAHLYDFDMSEHVIMIQD 260
            :.|.|.| ...||.|||:|....|| .:.|.:|:.  |||.     |..|      .|.||::.:
plant   109 YVYNFTVTGQRGTLWWHAHVLWLRA-TVHGAIVIL--PKLGLPYPFPKPH------REEVIILGE 164

  Fly   261 WVHNFVESVAENILINGRGRNLKKG-VKAAKPTLYAHFP--------VVRGGRYRFRVIFNGVSN 316
            |..:..|:|....|.:|...|:... |....|....:.|        |..|..|..|:| |...|
plant   165 WWKSDTETVVNEALKSGLAPNVSDAHVINGHPGFVPNCPSQGNFKLAVESGKTYMLRLI-NAALN 228

  Fly   317 CPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFCAKNQ 381
            ..:.|.|..|...|:..|...::|.....|:....:....::.|.:....|.|
plant   229 EELFFKIAGHRFTVVEVDAVYVKPFNTDTILIAPGQTTTALVSAARPSGQYLI------------ 281

  Fly   382 LHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSISLAN--------LNAQ 438
                |...::|:...|:|..|.:......| ||:......:.....|:.|:||        ||::
plant   282 ----AAAPFQDSAVVAVDNRTATATVHYSG-TLSATPTKTTSPPPQNATSVANTFVNSLRSLNSK 341

  Fly   439 RPEPEVAPSV----TFYTSMNAFEVRQGEGFRFQ-----MDDISFSMPKMSLLQTRNLGVGQFFC 494
            .....|..:|    .|...:........:...|.     :::|:|.|||.:|||..       :.
plant   342 TYPANVPITVDHDLLFTVGLGINRCHSCKAGNFSRVVAAINNITFKMPKTALLQAH-------YF 399

  Fly   495 NRSQQADLGFNCRQRH--------------CQCSNVIQVPANQQVEFVI---SSLSQTPHPIHLH 542
            |.:......|..:.|.              .:.:.:.::|.|..|:.|:   .:::...||||||
plant   400 NLTGIYTTDFPAKPRRVFDFTGKPPSNLATMKATKLYKLPYNSTVQVVLQDTGNVAPENHPIHLH 464

  Fly   543 GYTFRVVGMGV------LGEQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSP 601
            |:.|.|||:|.      ....|...::.:::.|              |.||:.|:..:||.:::|
plant   465 GFNFFVVGLGTGNYNSKKDSNKFNLVDPVERNT--------------VGVPSGGWAAIRFRADNP 515

  Fly   602 GYWMFHCHISPHSENG--MAAVVRVGEDVEMKMCP 634
            |.|..|||:..|:..|  ||.:|..|:.....:.|
plant   516 GVWFMHCHLEVHTTWGLKMAFLVENGKGPNQSIRP 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	135/545 (25%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	37/98 (38%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	30/145 (21%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	47/194 (24%)
LAC10	NP_195739.2	laccase	22..558	CDD:274556	137/555 (25%)
		CuRO_1_LCC_plant	27..143	CDD:259918	37/101 (37%)
		CuRO_2_LCC_plant	158..305	CDD:259943	33/163 (20%)
		CuRO_3_LCC_plant	404..541	CDD:259964	37/150 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930