DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and AT4G39830

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_195693.1	Gene:	AT4G39830 / 830142	AraportID:	AT4G39830	Length:	582	Species:	Arabidopsis thaliana

Alignment Length:	575	Identity:	166/575 - (28%)
Similarity:	251/575 - (43%)	Gaps:	107/575 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 KYADGLESEVMVVNGQLPGMNIEVCYGDTVVADVINS-MHETTTIHWHGMHQRLTPFMDGVPHVT 192
            |..|..|..|:.:||:.||..|:...|||:|.::.|| |.|...:||||:.|..||:.|||..||
plant    47 KSPDCFEKLVITINGKFPGPTIKAQQGDTIVVELKNSFMTENVAVHWHGIRQIGTPWFDGVEGVT 111

  Fly   193 QYPIEAGQAFRYRFEVDHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDFDMSEHVIM 257
            |.||..|:.|.|:|.||..||..:|||...||..||.|.:.| .||...|....||:|.:   .:
plant   112 QCPILPGEVFIYQFVVDRPGTYMYHSHYGMQRESGLIGMIQV-SPPATEPEPFTYDYDRN---FL 172

  Fly   258 IQDWVHNFVESVA--------------ENILINGRGR-----------NLKKGVKAAKPTLYAHF 297
            :.||.|..:...|              ::::|.||||           :|..||........:.|
plant   173 LTDWYHKSMSEKATGLASIPFKWVGEPQSLMIQGRGRFNCSNNLTTPPSLVSGVCNVSNADCSRF 237

  Fly   298 --PVVRGGRYRFRV-IFNGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLH 359
              .|:.|..||.|: ....:|  .:||.|:.|:|.|:.:||:.:||..|:.:..:..|.:..:|.
plant   238 ILTVIPGKTYRLRIGSLTALS--ALSFQIEGHNLTVVEADGHYVEPFTVKNLFVYSGETYSVLLK 300

  Fly   360 ANQEV-SNYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELGDDASG 423
            |:|.. .||||.....|..|... ...|||:|.....|.          ..|....:.:..:.:.
plant   301 ADQNPRRNYWITSSIVSRPATTP-PATAVLNYYPNHPRR----------RPPTSESSNIVPEWND 354

  Fly   424 ARAGNSISLANLNAQR------PE--PEVAPSVTFYTSMNAFEVRQGEGFRFQMDDISFSMPKMS 480
            .|:..:.||| :.|:|      ||  .:|...:.....:|.:.       |:.::::|:..||..
plant   355 TRSRLAQSLA-IKARRGFIHALPENSDKVIVLLNTQNEVNGYR-------RWSVNNVSYHHPKTP 411

  Fly   481 LLQTRNLGVGQFFCNRSQQADLGFNCRQRH----------------CQCSNVIQVPANQQVEFVI 529
            .|    :.:.|   |.:...|..|...:.:                .....:.::..|..|:.::
plant   412 YL----IALKQ---NLTNAFDWRFTAPENYDSRNYDIFAKPLNANATTSDGIYRLRFNSTVDVIL 469

  Fly   530 SSL-------SQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGA-PL-KDSVQ 585
            .:.       |:| ||.||||:.|.|:|   .||.|..:.|.       |:|.... |: |::|.
plant   470 QNANTMNANNSET-HPWHLHGHDFWVLG---YGEGKFNESED-------PKRYNRVDPIKKNTVA 523

  Fly   586 VPAFGYTILRFYSNSPGYWMFHCHISPHSENGMAAVVRVGED-VEMKMCPVSNCG 639
            |..||:|.|||.:::||.|.|||||..|...||..|...|.| |......:..||
plant   524 VQPFGWTALRFRADNPGVWSFHCHIESHFFMGMGIVFESGIDKVSSLPSSIMGCG 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	160/556 (29%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	47/103 (46%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	43/165 (26%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	52/190 (27%)
AT4G39830	NP_195693.1	PLN02604	10..582	CDD:215324	166/575 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	120	1.000	Domainoid score	I1881
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H135473
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58299
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790