DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and LAC6

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_182180.1	Gene:	LAC6 / 819269	AraportID:	AT2G46570	Length:	569	Species:	Arabidopsis thaliana

Alignment Length:	545	Identity:	154/545 - (28%)
Similarity:	250/545 - (45%)	Gaps:	89/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 SEVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQ 200
            :|::.||.:.||..|.....|.:|..|||.....|||||||:.|:.:.:.||..::||.||::||
plant    50 NEIVTVNKKFPGPAISAQEDDRIVIKVINMTPYNTTIHWHGIKQKRSCWYDGPSYITQCPIQSGQ 114

  Fly   201 AFRYRFEV-DHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLN-PHAHLYDFDMSEHVIMIQD-WV 262
            :|.|.|:| ...||..||:|....|| .:.|||:|.  ||.: |:.....|  :||.|::.: |:
plant   115 SFTYNFKVAQQKGTFLWHAHFSWLRA-TVYGPLIVY--PKASVPYPFKKPF--NEHTILLGEYWL 174

  Fly   263 HNFVE------------SVAENILINGR-GRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNGV 314
            .|.||            ..|:...|||: |.|    ...:...:| ...:|....|..|:|..|:
plant   175 KNVVELEQHVLESGGPPPPADAFTINGQPGPN----YNCSSKDVY-EIQIVPRKIYLLRLINAGI 234

  Fly   315 SNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFCAK 379
             |....|:|..|.|.::..||...:|...:|:|....:..:.::.|:|.|..|.:.:..|. .||
plant   235 -NMETFFTIANHRLTIVEVDGEYTKPYTTERVMLVPGQTMNILVTADQTVGRYSMAMGPYE-SAK 297

  Fly   380 NQLHQEAVLHYRDADTRALDTHTLSYAY--------DAPGKTLNELGDDAS------GARAGNSI 430
            |...|         :|.|:    .::.|        ..|.| |....|:.:      |.|:.|::
plant   298 NVKFQ---------NTSAI----ANFQYIGALPNNVTVPAK-LPIFNDNIAVKTVMDGLRSLNAV 348

  Fly   431 SL-ANLNAQRPEPEVAPSVTFYTSMNAFEVRQG--EG-FRFQMDDISFSMPKMSLLQT--RNLGV 489
            .: .|::|.. ...:..:|....|.|.....||  :| ....|::|||..||:|:|:.  :.| .
plant   349 DVPRNIDAHL-FITIGLNVNKCNSENPNNKCQGPRKGRLAASMNNISFIEPKVSILEAYYKQL-E 411

  Fly   490 GQF---FCNRSQQA---------DLGFNCRQRHCQCSNVIQVPANQQVEFV-ISSLSQTPHPIHL 541
            |.|   |....::|         |:..:.:..:...:.|.:..:..|:.|. ..:|:...|||||
plant   412 GYFTLDFPTTPEKAYDFVNGAPNDIANDTQAANGTRAIVFEYGSRIQIIFQNTGTLTTENHPIHL 476

  Fly   542 HGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYWMF 606
            ||::|.|:|.|.      |..:|...|..|    :..|..:::.||..|:..:||.:|:||.|:.
plant   477 HGHSFYVIGYGT------GNYDQQTAKFNL----EDPPYLNTIGVPVGGWAAIRFVANNPGLWLL 531

  Fly   607 HCHISPHSENGMAA--VVRVGEDVE 629
            |||...|...||:.  :|:.|:.|:
plant   532 HCHFDIHQTWGMSTMFIVKNGKKVQ 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	152/540 (28%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	41/99 (41%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	38/150 (25%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	52/179 (29%)
LAC6	NP_182180.1	laccase	29..569	CDD:274556	154/545 (28%)
		CuRO_1_LCC_plant	34..150	CDD:259918	42/102 (41%)
		CuRO_2_LCC_plant	165..312	CDD:259943	39/166 (23%)
		CuRO_3_LCC_plant	413..552	CDD:259964	40/148 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830