DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and LAC5

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_181568.1	Gene:	LAC5 / 818630	AraportID:	AT2G40370	Length:	580	Species:	Arabidopsis thaliana

Alignment Length:	569	Identity:	151/569 - (26%)
Similarity:	235/569 - (41%)	Gaps:	131/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 MVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAFR 203
            :.|||..||..:.|..|||:|..|||......||||||:.|..|.:.||...|||.||..|.::.
plant    50 ITVNGMFPGPMLVVNNGDTLVVKVINRARYNITIHWHGVRQMRTGWADGPEFVTQCPIRPGSSYT 114

  Fly   204 YRFEVD-HGGTNWWHSHTEHQRAFGLAGPLVVRMP-----PKLNPHAHLYDFDMSEHVIMIQDWV 262
            |||.:. ..||.|||:|:...|| .:.|.|:|..|     |...||.::       .:::.:.|.
plant   115 YRFTIQGQEGTLWWHAHSSWLRA-TVYGSLLVFPPAGSSYPFTKPHRNV-------PLLLGEWWD 171

  Fly   263 HNFVESVAENI------------LINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNGVS 315
            .|.|:.:.|:|            .|||:..:|.| ..:...|:   .|:..|.....||| |...
plant   172 ANPVDVLRESIRTGGAPNNSDAYTINGQPGDLYK-CSSQDTTV---VPINVGETILLRVI-NSAL 231

  Fly   316 NCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFCAKN 380
            |.|:.|::..|.|.|:.:|.:.::|.....|:....:..|.::..:|..:.|::..:.|. .|:|
plant   232 NQPLFFTVANHKLTVVGADASYLKPFTTNVIVLGPGQTTDVLITGDQPPNRYYMAARAYQ-SAQN 295

  Fly   381 ----QLHQEAVLHYRDADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSI----------- 430
                .....|:|.|:.|....:                    ...||.:.|||.
plant   296 APFGNTTTTAILQYKSAPCCGV--------------------GGGSGTKKGNSFKPIMPILPAYN 340

  Fly   431 ----------SLANLNAQRPEPEVAPS--VTFYTSMN----AFEVRQGEG-----FRFQMDDISF 474
                      |..:|.......|:..:  ||....:|    .|..|:.:|     |...|:::||
plant   341 DTNTVTRFSQSFRSLRRAEVPTEIDENLFVTIGLGLNNCPKNFRSRRCQGPNGTRFTASMNNVSF 405

  Fly   475 SMP-KMSLLQTRNLGVGQFF------------------CNRS-QQADLGFNCRQRHCQCSNVIQV 519
            ::| ..||||..:.|:...|                  .:|| .|.|.|          :.:.::
plant   406 ALPSNYSLLQAHHHGIPGVFTTDFPAKPPVKFDYTGNNISRSLYQPDRG----------TKLYKL 460

  Fly   520 PANQQVEFVISSLS-QTP--HPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLK 581
            ....:|:.|:.... .||  ||||||||.|.::..|      .|...  .||.......:..||:
plant   461 KYGSRVQIVLQDTGIVTPENHPIHLHGYDFYIIAEG------FGNFN--PKKDTAKFNLEDPPLR 517

  Fly   582 DSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSENG--MAAVVRVGEDV 628
            ::|.||..|:.::||.:::||.|:.|||:..|...|  ||.:|..|..|
plant   518 NTVGVPVNGWAVIRFIADNPGVWIMHCHLDAHISWGLAMAFLVENGNGV 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	149/565 (26%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	42/96 (44%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	34/152 (22%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	53/186 (28%)
LAC5	NP_181568.1	laccase	27..580	CDD:274556	151/569 (27%)
		CuRO_1_LCC_plant	31..147	CDD:259918	43/97 (44%)
		CuRO_2_LCC_plant	162..309	CDD:259943	34/159 (21%)
		CuRO_3_LCC_plant	424..563	CDD:259964	42/156 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930