DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and LAC2

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_180477.1	Gene:	LAC2 / 817462	AraportID:	AT2G29130	Length:	573	Species:	Arabidopsis thaliana

Alignment Length:	552	Identity:	144/552 - (26%)
Similarity:	234/552 - (42%)	Gaps:	91/552 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 VMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAF 202
            ::.|||:.||..:....||.:...|:|.:....:|||||:.|..:.:.||..:|||.||..||::
plant    50 IVTVNGKFPGPRVTAREGDNLQIKVVNHVSNNISIHWHGIRQLRSGWADGPSYVTQCPIRMGQSY 114

  Fly   203 RYRFEV-DHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDF--DMSEHVIMIQDWVHN 264
            .|.|.| ...||.|||:|.:..|| .:.|||::.  |||:   ..|.|  ...:..|:..:|.:.
plant   115 VYNFTVTGQRGTLWWHAHIQWMRA-TVYGPLIIL--PKLH---QPYPFPKPYKQVPILFGEWFNA 173

  Fly   265 FVESVAENILINGRGRNLKKGVKAAKPTLYAHFP--------------VVRGGR-YRFRVIFNGV 314
            ..::|.:..|..|.|.|      |:....:...|              :|:.|: |..|:| |..
plant   174 DPQAVVQQALQTGAGPN------ASDAHTFNGLPGPLYNCSTKDTYKLMVKPGKTYLLRLI-NAA 231

  Fly   315 SNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSN--YWIRVKGYSFC 377
            .|..:.|:|..|.|.|:.:|...::|.:...::....:..:.:|.......|  :::..:.| |.
plant   232 LNDELFFTIANHTLTVVEADACYVKPFQTNIVLLGPGQTTNVLLKTKPIYPNATFYMLARPY-FT 295

  Fly   378 AKNQLHQEAV---LHYRDADTRALDTHTLSYAYDAPGKTLN----ELGDDASGARAGNSI----S 431
            .:..:....|   |.|:.        ||.|      .|.|:    .|....|.:.|.|..    |
plant   296 GQGTIDNTTVAGILQYQH--------HTKS------SKNLSIIKPSLPPINSTSYAANFTKMFRS 346

  Fly   432 LANLNAQRPEPEVAPSVTFYT---SMNAFEVRQG-EG------FRFQMDDISFSMP-KMSLLQTR 485
            ||:.......|:|.....|:.   ..|.....|. :|      |...::::||.:| |.||||:.
plant   347 LASSTFPANVPKVVDKQYFFAIGLGTNPCPKNQTCQGPTNTTKFAASINNVSFILPNKTSLLQSY 411

  Fly   486 NLGVGQ--FFCNRSQQADLGFNC------RQRHCQCSNVIQVPANQQVEFVI---SSLSQTPHPI 539
            .:|..:  |..:......:.||.      .....:.:.|:.:.....||.|:   |.|....|||
plant   412 FVGKSKNVFMTDFPTAPIIPFNYTGTPPNNTMVSRGTKVVVLKYKTTVELVLQGTSILGIEAHPI 476

  Fly   540 HLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYW 604
            ||||:.|.|||.|..........:..:...|:.|        :::.:|:.|:..:||.:::||.|
plant   477 HLHGFNFYVVGQGFGNFNPARDPKHYNLVDPVER--------NTINIPSGGWVAIRFLADNPGVW 533

  Fly   605 MFHCHISPHSENG--MAAVVRVGEDVEMKMCP 634
            :.||||..|...|  ||.||..|:....|:.|
plant   534 LMHCHIEIHLSWGLTMAWVVLDGDLPNQKLLP 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	141/542 (26%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	38/97 (39%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	29/156 (19%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	51/178 (29%)
LAC2	NP_180477.1	laccase	27..573	CDD:274556	144/552 (26%)
		CuRO_1_LCC_plant	32..148	CDD:259918	38/100 (38%)
		CuRO_2_LCC_plant	163..311	CDD:259943	29/155 (19%)
		CuRO_3_LCC_plant	419..556	CDD:259964	40/144 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X253
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930