DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and Hephl1

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001178922.2	Gene:	Hephl1 / 500946	RGDID:	1564835	Length:	1159	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	112/624 - (17%)
Similarity:	204/624 - (32%)	Gaps:	190/624 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DKQPMTCYYYMVVHYDDTMA----ETCKRYLQSKFRFKLSGKEYIDGIALATQLAANDDCKYADG 133
            ||:    :|.:...:|:..:    |..:::....|......||::.
  Rat   575 DKE----FYLLFTVFDENFSSYLDENIQKFTWHPFSVDKEDKEFVK------------------- 616

  Fly   134 LESEVMVVNGQL----PGMNIEVCYGDTVVADVI-----NSMH----ETTTIHWHGMHQ-RLTPF 184
             .:.:..:||.:    ||::  :|..|.|...:|     ..||    :..|||..|.|: .|..|
  Rat   617 -SNRMHAINGYMYGNQPGLS--MCKKDRVSWHLIGMGTDTDMHGVYFQGNTIHLRGTHRDSLALF 678

  Fly   185 MDGVPHVTQYPIEAGQAFRYRFEVDHGGTNWWHSHTEHQRAFGLAGPLVV----RMPPKLNPHAH 245
                ||::.      .||   .:.||.|.......|.|....|:.....|    ...|...|:..
  Rat   679 ----PHMST------TAF---MQPDHSGIFKVFCSTLHHFTRGMGQIYEVSSCGNRDPSEPPYGM 730

  Fly   246 LYDFDMSEHVIMIQDWVHNFVESVAENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVI 310
            |..|.::...:   :|      ..|.|.......::|..|.:........|.....|.:|| :|:
  Rat   731 LRTFYIAAEEV---EW------DYAPNKNWEFEKQHLDAGGERHGDIFMNHTENWIGSQYR-KVV 785

  Fly   311 FNGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHGAERFD--FVLHANQEVSNYWIRVKG 373
            :...:|         .:.|.|.:.....|.:::...|.| ||..|  .::..|:....|.|..:|
  Rat   786 YREYTN---------GEFVEIKARPPQEEHLQLLGPMIH-AEVGDSILIIFKNKASRPYSITAQG 840

  Fly   374 YSFCAKNQLHQEAVLHYRDADT-RALDT------HTLSYAYDAPGKTLNELGDDASGARAGNSIS 431
                            ..|:|: :.||.      ...:|.::.|             .|:|...|
  Rat   841 ----------------VEDSDSGKFLDVPVTKPGEIKTYRWNVP-------------KRSGPGPS 876

  Fly   432 LANLNAQRPEPEVAPSVTFYTSMNAFEVRQG---------EGF---RFQMDDISFSMPKMSLLQT 484
                     :|...|.|.|.|:....:...|         ||.   :.:..|:.:....:.|:..
  Rat   877 ---------DPNCIPWVYFSTANFVKDTYSGLMGPLITCREGVLNEKGRRSDVDYEFALLFLVFN 932

  Fly   485 RNLGVGQFFCNRSQQADLGFNCRQ-RHC---QCSNVIQVPANQQVEFVISSLSQTP--------- 536
            .|   ..::.:.:.:..|..:.|. ||.   :.||.:.. .|.::...:..|..|.
  Rat   933 EN---ESWYLDDNIKKYLNKDPRDFRHTDDFEESNRMHA-INGKIFGNLPGLIMTEDSMTNWYLL 993

  Fly   537 --------HPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTI 593
                    |.||.|..:|               :.:|||          :..:|...:....:..
  Rat   994 GIGSEVDIHTIHYHAESF---------------LFKIDK----------SYREDVYDLFPGTFQT 1033

  Fly   594 LRFYSNSPGYWMFHCHISPHSENGMAAVVRVGEDVEMKM 632
            :..:::.||.|:.|||:|.|...||.....|..:::.::
  Rat  1034 IELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRI 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	104/553 (19%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	28/120 (23%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	23/138 (17%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	32/186 (17%)
Hephl1	NP_001178922.2	CuRO_1_ceruloplasmin	26..208	CDD:259884
		CuRO_2_ceruloplasmin	222..362	CDD:259907
		CuRO_3_ceruloplasmin	376..572	CDD:259886
		CuRO_4_ceruloplasmin	575..718	CDD:259908	36/181 (20%)
		Cupredoxin	732..907	CDD:418529	39/232 (17%)
		Cupredoxin	923..1065	CDD:418529	30/170 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110