DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and Mco1

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001188754.1	Gene:	Mco1 / 34258	FlyBaseID:	FBgn0032116	Length:	959	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	259/737 - (35%)
Similarity:	354/737 - (48%)	Gaps:	148/737 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QDASGKRIVSK----YERIMQ--MYPQLSSGAGESSQ--WRAAEKDNQRHPCRRDC-ADKQPMTC 79
            :|....|:..:    |.|.:|  ...:|.....||:.  |.|....|  |||.||| ...:||||
  Fly   196 EDCPASRLEERNCCPYCRPLQTARIEELQDNVAESTDDIWTAEWYRN--HPCNRDCQVGAEPMTC 258

  Fly    80 YYYMVVHYDDTMAET---CKRYLQSKFRFKLSGKEYIDGIALATQLAANDDCKYADGLESEVMVV 141
            .|..||.:..|.::.   |.|.|..                     .:...|...||||..:.||
  Fly   259 RYKFVVEWYQTFSKACYDCPRNLTD---------------------CSRPHCVMGDGLERSITVV 302

  Fly   142 NGQLPGMNIEVCYGDTVVADVINS-MHETTTIHWHGMHQRLTPFMDGVPHVTQYPIEAGQAFRYR 205
            |..:||..||||.||.:|.||.|. :.|:|:|||||:||:.||:||||||:||.||.....|||.
  Fly   303 NRMMPGPAIEVCEGDEIVVDVKNHLLGESTSIHWHGLHQKKTPYMDGVPHITQCPITPHATFRYS 367

  Fly   206 FEVDHGGTNWWHSHTEHQRAFGLAGPLVVRMPPKLNPHAHLYDFDMSEHVIMIQDWVHNFVESV- 269
            |..|..||::|||||..||..|:.|.|::|.|....||..|||||:||||:::|||:|:...|:
  Fly   368 FPADLSGTHFWHSHTGMQRGDGVFGALIIRKPKTAEPHGGLYDFDLSEHVMIVQDWIHDTGASIF 432

  Fly   270 -----------AENILINGRGR------------------------------------NLKKGVK 287
                       ..|:|:||:||                                    .|.:..:
  Fly   433 SYHHHSRGDNKPHNLLVNGKGRYYNRIWAEAKQAHRRAEERTTQPVEPLPKSQVDFVQTLPRQAR 497

  Fly   288 AAKPTLYAHFP------------------------VVRGGRYRFRVIFNGVSNCPISFSIDKHDL 328
            .||......||                        |.||.|||||:|.....||||..|||.|:|
  Fly   498 LAKTNTTKLFPVNSRQKRGNLNEIPLELVPHQIYTVRRGFRYRFRIINAEYLNCPIVVSIDGHNL 562

  Fly   329 VVIASDGNDIEPVEVQRIMFHGAERFDFVLHANQEVSNYWIRVKGYSFCAK--NQLHQEAVLHYR 391
            ..|.|||.|||.::|..|:.:..|||||||:||.||.|||||:||...|::  ....|.|:|.|.
  Fly   563 TAINSDGFDIEAMDVGSIVTYSGERFDFVLNANLEVGNYWIRLKGLMDCSEVFTSAFQVAILRYE 627

  Fly   392 DADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSISLANLNA--------------QRPEP 442
            .|.... .|..|||.:.|.|..||.:.   .|....::.::|.:.|              .:||.
  Fly   628 GAPDEE-PTAELSYGHKAEGIELNVMN---RGPGYPDTKTVAEMRALPIYDHVSGIDHDTLKPEA 688

  Fly   443 EVAPSV--TFYTSMN---------AFEV---RQGEGFRFQMDDISFSMPKMSLLQTRNLGVGQFF 493
            :....:  .|||..|         |.::   :|...:..|::.|:.:.|.::||.:|:......|
  Fly   689 DYKFFIYYDFYTKNNPDFHDKDLYAMDMEMTQQNRLYTPQLNHITLNFPSLALLPSRSQLKDSDF 753

  Fly   494 CNRSQQADLGFNCRQRHCQCSNVIQVPANQQVEFVISSLS---QTPHPIHLHGYTFRVVGMGVLG 555
            ||.:...|.|.:|||..|:|.:|:|||....||.:|....   ...||.||||..|||:|:..||
  Fly   754 CNETSLMDQGIDCRQEFCKCHHVLQVPLGAVVEMIIVDEGFQYYANHPFHLHGNAFRVMGLERLG 818

  Fly   556 EQ-KIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSENGMA 619
            |. .:..|:|:|:...|.|.....|:||:|.:|..||||:||.:::||||:|||||..|:|.|||
  Fly   819 ENVTVEMIKQLDQFNLLKRNLDNPPVKDTVTIPDGGYTIIRFEASNPGYWLFHCHIEFHAEIGMA 883

  Fly   620 AVVRVGEDVEMKMCPVS--NCG 639
            .|.:||.|.:|...|.:  .||
  Fly   884 LVFKVGNDDQMVPVPENFPTCG 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	224/600 (37%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	57/103 (55%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	68/210 (32%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	71/168 (42%)
Mco1	NP_001188754.1	VWC	150..212	CDD:214564	2/15 (13%)
		ascorbase	293..905	CDD:274555	228/615 (37%)
		CuRO_1_tcLCC2_insect_like	293..397	CDD:259927	57/103 (55%)
		CuRO_2_tcLCC_insect_like	415..626	CDD:259951	68/210 (32%)
		CuRO_3_tcLLC2_insect_like	728..897	CDD:259972	71/168 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470271
Domainoid	1	1.000	120	1.000	Domainoid score	I1881
eggNOG	1	0.900	-	-		E1_COG2132
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I1224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257925at33208
OrthoFinder	1	1.000	-	-		FOG0000424
OrthoInspector	1	1.000	-	-		mtm1062
orthoMCL	1	0.900	-	-		OOG6_100257
Panther	1	1.100	-	-	P	PTHR11709
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X253
	11	10.800