DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and F5

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_038946712.1	Gene:	F5 / 304929	RGDID:	1589758	Length:	2226	Species:	Rattus norvegicus

Alignment Length:	671	Identity:	132/671 - (19%)
Similarity:	228/671 - (33%)	Gaps:	212/671 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 YMVVHYDDTMA--ETCKRYLQSK-FRFKLSGKEYIDGIALATQLAANDDCKYADGLESEVMVVNG 143
            |.|.|..|.:|  ::.:..:|.| ...:.|.|.:: |..|...|....|.:|........:.:.|
  Rat    62 YTVSHNGDGIAKMQSSEGQVQEKQAEIRRSDKNHV-GAFLYVPLYVFHDLEYKQFQTYPSLGLLG 125

  Fly   144 QLPGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQ-YPIE-------AGQ 200
              |.:..||  |||:.....|...:..:||..|:  |.:.|.:|..::.. .|.|       ||:
  Rat   126 --PTLYAEV--GDTIKVHFRNKADKPLSIHPQGI--RYSKFSEGASYLDHTSPAERKDDAVAAGE 184

  Fly   201 AFRYRFEV--DHGG--------TNWWHSHTEHQRAF--GLAGPLVVRMPPKLNPHAHLYDFDMSE 253
            .:.|.:.:  |.|.        |:.::|:....:.|  ||.|||::.....|........|| .:
  Rat   185 EYTYEWFIGEDSGPTPDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKEGTLTEDGTQKMFD-KQ 248

  Fly   254 HVIM--IQDWVHNFVESVAENILING-RGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNG-- 313
            ||::  :.|...::.:|.|....:|| ..|.:......|...:..|...:..|...|.:.|||
  Rat   249 HVLLFAVFDESKSWSQSPALMYTVNGFVNRTMPDVTVCAYDHVSWHLIGMSSGPELFSIHFNGQV 313

  Fly   314 -------VSNCPISFSIDKHDLVVIASDGN-------------------DIEPV----------- 341
                   ||...:..:......:.::.:|.                   ||:..
  Rat   314 LEQNQHKVSTVTLVSATSTTANMTMSPEGKWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSSKTLT 378

  Fly   342 -EVQRIMFHGAERFDFVLHANQEVSNY-------------WIRVKGYSFCAKNQL--HQEAVLH- 389
             |.:|.|    :|:::.:.|.:.:.||             .:.:..:|    ||:  |.:.|::
  Rat   379 REQRRHM----KRWEYFIAAEEVIWNYAPVIPANMDKLYKSLHLDNFS----NQIGKHYKKVIYR 435

  Fly   390 -YRDADTRALDTHTLSYAYDAPGKTLNELGDDASG-------ARAGNSISLANLN-AQRPEPEVA 445
             |:|      :|.|         |.:.......||       |:..:::.:...| |.||.....
  Rat   436 EYKD------ETFT---------KRIENQSSRQSGILGPIIKAQVRDTLKIVFKNMASRPYSIYP 485

  Fly   446 PSVTF---------------YTSMNAFEVRQGEGFRFQMDDISFSMPKMSLLQ------------ 483
            ..|||               :|.:.  .|:.||.|.::.:.:.|..|..:..|
  Rat   486 HGVTFSPYEDGVNSSSTSGSHTMIK--PVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDV 548

  Fly   484 TRNLG---VGQFFCNRSQQADLGFNCRQRHCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHGYT 545
            ||::.   :|.....:|:..|      ||.      ||..|:.:.|.|.:
  Rat   549 TRDIASGLIGLLLICKSRSLD------QRG------IQRVADMEQEVVFA--------------- 586

  Fly   546 FRVVGMGVLGEQKIGQIE-QIDKKTPLPRRAKGAPLKDSVQVPAF----------GY-----TIL 594
                   :..|.|...|| .|:|....|...|    :|.   |.|          ||     :.|
  Rat   587 -------MFDENKSWYIEDNINKFCENPDEVK----RDD---PKFYESNIMNTINGYVPESISTL 637

  Fly   595 RFYSNSPGYWMFHCHISPHSE 615
            .|..:....|.| |.:..|.:
  Rat   638 GFCFDDAVQWHF-CSVGTHDD 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	118/618 (19%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	29/122 (24%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	32/196 (16%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	34/179 (19%)
F5	XP_038946712.1	Cupredoxin	<105..234	CDD:418529	31/134 (23%)
		Cupredoxin	246..364	CDD:418529	19/118 (16%)
		CuRO_3_FV_like	386..565	CDD:259992	35/199 (18%)
		Cupredoxin	578..721	CDD:418529	21/110 (19%)
		ARG80	<1090..1380	CDD:227400
		Cupredoxin	1582..1757	CDD:418529
		Cupredoxin	1769..1904	CDD:418529
		FA58C	1911..2062	CDD:238014
		FA58C	2070..2222	CDD:238014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110