DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and F8

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_899160.2	Gene:	F8 / 302470	RGDID:	727845	Length:	2258	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	96/514 - (18%)
Similarity:	169/514 - (32%)	Gaps:	172/514 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RDCADKQPMTCYYYMVVHYDD----TMAETCK------RYL-------QSKFRFKLSGKEYIDGI 116
            |..|.:.|.|..:|:.....|    ..|.|.:      |||       .||:: |:....|.||.
  Rat   379 RSAAKRHPKTWVHYIAAEEGDWDYAPAAATLEDGSLRNRYLGRGPGRIGSKYK-KVRFVAYTDGT 442

  Fly   117 ALATQLAANDDCKYADGLESEVMVVNGQLPGMNIEVCYGDTVVADVINSMHETTTIHWHG----- 176
            ....:....:.......|..||                ||:::....|.......||.||
  Rat   443 FHTREATPREAGLLGPLLYGEV----------------GDSLLIVFKNRASRAYNIHPHGIRDVG 491

  Fly   177 -MHQRLTPFMDGVPHVTQYPIEAGQAFRYRFEV--DHGG--------TNWWHSHTEHQR--AFGL 228
             :|....|  .||.||...||..|:.|:||:.:  :.|.        |.::.|..:.:|  |.||
  Rat   492 AVHAGRLP--RGVKHVKDLPIRPGETFKYRWTLTAEDGPARSDARCVTRYYASAVDPERDLASGL 554

  Fly   229 AGPLVVRMPPKLNPHAH-------------LYDFDMSEHV-------------IMIQDWVHNFVE 267
            .|||::.....::...:             ::|.:.|.::             :.:||     .|
  Rat   555 IGPLLICCKESVDQRGNQMMSDERNVILFSVFDENRSWYISENMRRFLPDEAHVQLQD-----PE 614

  Fly   268 SVAENIL--ING---RGRNLK-----------KGVKAAKPTLYAHFPVVRGGRYRFRVIF----- 311
            ..|.|::  |||   ....|:           ..|.|....|...|   .|..:|.|.::
  Rat   615 FEASNLMHSINGYVFDSLELRVCLHEVAAWHVLSVGAQTDFLSVFF---SGHTFRHRAVYADTLT 676

  Fly   312 ----NGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIM-----------FHGAERFDFV---- 357
                :||:   :..|:|...:.|:.....|.....:..::           ::| |.::.|
  Rat   677 VFPHSGVT---VFMSMDNPGVWVLGCHNPDFRESGMTALLKVSSCDEGVSDYYG-ETYEGVLAPL 737

  Fly   358 -----------------LHANQEVSN---------------YWIRVKGYSFCAKNQLHQEAVLHY 390
                             ||:.::.||               :|...:|....|.::.|..|..|.
  Rat   738 ANDNAVDPRSFSQNSNHLHSRKKKSNTPMRFPLSHPTQHGSFWSDSQGDVHDAVHRAHSPAAAHS 802

  Fly   391 RDADTRALDTHTLSYAYDAPGKTLNELGDDASGARAGNSISLANLNAQRPEPEVAPSVT 449
            .:....|.......:    ||:   ::....|..||..|: :..:.|:|.:.::...|:
  Rat   803 NEGPAEAAQLEPKPH----PGE---KMALPPSWLRAKRSL-VTTMEAKRKKLDLQVQVS 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	79/434 (18%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	32/120 (27%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	34/221 (15%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972
F8	NP_899160.2	Cupredoxin	22..199	CDD:418529
		Cupredoxin	212..336	CDD:418529
		Cupredoxin	387..563	CDD:418529	46/194 (24%)
		Cupredoxin	576..718	CDD:418529	24/152 (16%)
		Cupredoxin	1622..1785	CDD:418529
		Cupredoxin	1799..1942	CDD:418529
		FA58C	1950..2094	CDD:238014
		FA58C	2103..2251	CDD:238014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010