DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and F5

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_000121.2	Gene:	F5 / 2153	HGNCID:	3542	Length:	2224	Species:	Homo sapiens

Alignment Length:	465	Identity:	80/465 - (17%)
Similarity:	156/465 - (33%)	Gaps:	141/465 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ESEVMVVNGQL-PGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQRLTPFMDGVPHVTQ-YPIE 197
            |.....::|.| |.:..||  ||.:.....|...:..:||..|:  |.:...:|..::.. :|.|
Human    76 EKPQSTISGLLGPTLYAEV--GDIIKVHFKNKADKPLSIHPQGI--RYSKLSEGASYLDHTFPAE 136

  Fly   198 -------AGQAFRYRFEV--DHGGTN-----WWHSHTEHQRAF-----GLAGPLVVRMPPKLNPH 243
                   .|:.:.|.:.:  |.|.|:     ..|.:..|:...     ||.|||::.....|...
Human   137 KMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEG 201

  Fly   244 AHLYDFDMSEHVIMI-------QDWVHNFVESVAENILINGRGRNLKKGVKAAKPTLYAHFPV-- 299
            .....||  :.::::       :.|..:.......|..:||...::         |:.||..:
Human   202 GTQKTFD--KQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDI---------TVCAHDHISW 255

  Fly   300 ----VRGGRYRFRVIFNG---------VSNCPISFSIDKHDLVVIASDG----NDIEPVEVQRIM 347
                :..|...|.:.|||         ||...:..:......:.:..:|    :.:.|..:|..|
Human   256 HLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGM 320

  Fly   348 FHGAERFDFVLHANQEVSNYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGK 412
                              ..:|.:|.   |.|...:.:.:       ||....|...:.|....:
Human   321 ------------------QAYIDIKN---CPKKTRNLKKI-------TREQRRHMKRWEYFIAAE 357

  Fly   413 TLNELGDDASGARAGNSISLANLNAQRPEPEVAPSVTFYTS--MNAFEVRQGEGFR----FQMDD 471
            .:  :.|.|       .:..||::.:            |.|  ::.|..:.|:.::    .|.:|
Human   358 EV--IWDYA-------PVIPANMDKK------------YRSQHLDNFSNQIGKHYKKVMYTQYED 401

  Fly   472 ISFSMPKMSLLQTRNLGVGQFFCNRSQQADLGFNCRQRHCQCSNVIQVPANQQVEFVISSLSQTP 536
            .||:...::             .|..:...||           .:|:......::.|..:::..|
Human   402 ESFTKHTVN-------------PNMKEDGILG-----------PIIRAQVRDTLKIVFKNMASRP 442

  Fly   537 HPIHLHGYTF 546
            :.|:.||.||
Human   443 YSIYPHGVTF 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	80/465 (17%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	28/120 (23%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	22/162 (14%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	15/79 (19%)
F5	NP_000121.2	Cupredoxin	32..196	CDD:302766	28/123 (23%)
		Cupredoxin	208..326	CDD:302766	20/146 (14%)
		CuRO_3_FV_like	348..528	CDD:259992	24/150 (16%)
		CuRO_4_FV_like	541..684	CDD:259996
		B	692..1573
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..927
		2 X 17 AA tandem repeats	895..928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	982..1001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1029..1048
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1157
		35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T	1185..1501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1341..1367
		CuRO_5_FV_like	1579..1754	CDD:259993
		Cupredoxin	1766..1902	CDD:302766
		FA58C	1906..2061	CDD:214572
		FA58C	1909..2060	CDD:238014
		FA58C	2065..2221	CDD:214572
		FA58C	2068..2220	CDD:238014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010