DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and Heph

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001153099.1	Gene:	Heph / 15203	MGIID:	1332240	Length:	1157	Species:	Mus musculus

Alignment Length:	646	Identity:	115/646 - (17%)
Similarity:	191/646 - (29%)	Gaps:	228/646 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ESSQWRAAEKDNQRHPCRRDCADKQPMTCYYYMVVHYDDTMAETCKRYLQSKFRFKLSGKEYIDG 115
            :..||..|.|.       |:....|.:.         :||:|.:          |..|||..|..
Mouse    33 QDMQWNYAPKG-------RNVITNQTLN---------NDTVASS----------FLKSGKNRIGS 71

  Fly   116 IALATQLAANDDCKYADGLESEVMVVNGQL----PGMNIEVCYGDTVVADVINSMHETTTIHWHG 176
            ....|...     :|:||..:|.:.....|    |.:..||  ||.::..:.|......|||.||
Mouse    72 SYKKTVYK-----EYSDGTYTEEIAKPAWLGFLGPLLQAEV--GDVILIHLKNFASRPYTIHPHG 129

  Fly   177 MHQR------LTP-----FM---DGVP----HVTQYPIEAGQAFRYRFEVDHGGTNW-WHSHTEH 222
            :...      |.|     ::   |.||    ||..:.|....|   ..|.|.....| :|||.:.
Mouse   130 VFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWSIPESHA---PTEADPACLTWIYHSHVDA 191

  Fly   223 QR--AFGLAGPLVV--------RMPPKLNPHAH-------LYDFDMSEHVIMIQDWVHNFVESVA 270
            .|  |.||.|||:.        ..||:.....|       :.|.::|.|   :.|.:..:....|
Mouse   192 PRDIATGLIGPLITCKRGTLDGNSPPQRKDVDHNFFLLFSVIDENLSWH---LDDNIATYCSDPA 253

  Fly   271 ENILINGRGRNLKKGVKAAKPTLYAHFPVVRGGRYRFRVIFNGVSNCPISFSIDKHDLVVIASDG 335
            .....:|..::..: :.|....::.:.|                   .:|....||....:...|
Mouse   254 SVDKEDGAFQDSNR-MHAINGFVFGNLP-------------------ELSMCAQKHVAWHLFGMG 298

  Fly   336 NDIEPVEVQRIMFHG------------AERFDFVLHANQEV---SNYWIRVKGYSFCAKNQLHQE 385
            |:|   :|....|||            |..|.......:.|   |..|:     ..|..|...:.
Mouse   299 NEI---DVHTAFFHGQMLSIRGHHTDVANIFPATFVTAEMVPQKSGTWL-----ISCEVNSHLRS 355

  Fly   386 AVLHYRDADTRALD----------------THTLSYAYDAPGKTLNELGDDASGARAGNSISLAN 434
            .:..:...|:.::|                .|.:.:.|       ..:|.|   .|.|.|:.
Mouse   356 GMQAFYKVDSCSMDPPVDQLTGKVRQYFIQAHEIQWDY-------GPIGYD---GRTGKSLR--- 407

  Fly   435 LNAQRPEPEVAPSVTFYTSMN---------AFEVRQGEGFRFQMDDISFSMPKMSLLQTRNLGVG 490
                  ||...|...|..|.:         .:|..|.|.|:.::
Mouse   408 ------EPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERV--------------------- 445

  Fly   491 QFFCNRSQQADLGFNCRQRHCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMGVLG 555
                ::.::..||.        ...||:......::.|..:.:..|..|..||..:.
Mouse   446 ----HQEEETHLGI--------LGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYE-------- 490

  Fly   556 EQKIGQIEQIDKKTPLPRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSEN 616
                             :.::|....|....|    .:.:.:.....||....|..|.:::
Mouse   491 -----------------KNSEGTVYNDGTSHP----KVAKSFEKVTYYWTVPPHAGPTAQD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	99/565 (18%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	37/135 (27%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	23/151 (15%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	16/149 (11%)
Heph	NP_001153099.1	CuRO_1_ceruloplasmin	26..208	CDD:259884	53/210 (25%)
		CuRO_2_ceruloplasmin	223..363	CDD:259907	26/170 (15%)
		CuRO_3_ceruloplasmin	377..571	CDD:259886	32/235 (14%)
		Cupredoxin	574..717	CDD:302766
		CuRO_5_ceruloplasmin	732..903	CDD:259887
		Cupredoxin	919..1062	CDD:302766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010