DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mco4 and CP

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_011510737.1	Gene:	CP / 1356	HGNCID:	2295	Length:	1094	Species:	Homo sapiens

Alignment Length:	635	Identity:	107/635 - (16%)
Similarity:	182/635 - (28%)	Gaps:	226/635 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RRDCADKQPMTCYYYMVVHYDDTMAETCKRYLQSKFRFKLSGKEYIDGIALATQLAANDDCKYAD 132
            |:...||:    :|.....:|    |.....|:...|...:..:.:|        ..::|.:.::
Human   570 RQKDVDKE----FYLFPTVFD----ENESLLLEDNIRMFTTAPDQVD--------KEDEDFQESN 618

  Fly   133 GLESEVMVVNGQLPGMNIEVCYGDTVV---------ADVINSMHETTTIHWHGMHQ---RLTPFM 185
            .:.|....:.|..||:.  :|.||:||         |||........|..|.|..:   .|.|..
Human   619 KMHSMNGFMYGNQPGLT--MCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQT 681

  Fly   186 DGVPHVTQYPIEAGQAFRYRFEVDH--GG------TNWWHSHTEH------QRAFGLAGPLVVRM 236
            ....|:  :|...|.........||  ||      .|.....:|.      :|.:.:|...|
Human   682 SLTLHM--WPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEV--- 741

  Fly   237 PPKLNPHAHLYDFDMSEHVIMIQDW---VHNFVESVAENILINGRGRNLKKGVKAAKPTLYAHFP 298
                       ::|.|..    ::|   :|:..|....|..::             |...|.
Human   742 -----------EWDYSPQ----REWEKELHHLQEQNVSNAFLD-------------KGEFYI--- 775

  Fly   299 VVRGGRYR---FRVIFNGVSNCPISFSIDKHDLVVI-----ASDGNDIEPVEVQRIMFHGAERFD 355
               |.:|:   :|...:.....|:....::..|.::     |..|:.:      :|:|..
Human   776 ---GSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKV------KIIFKN----- 826

  Fly   356 FVLHANQEVSNYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALDTHTLSYAYDAPGK-------- 412
                         :..:.||      :|...|.......|..|...||:|.:..|.:
Human   827 -------------MATRPYS------IHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDS 872

  Fly   413 ---------TLNELGDDASGARAGNSISLAN--LNAQRPEPEVAPSVTF---------YTSMNAF 457
                     |::::.|..||. .|..|....  |....|..::..::.|         |...| .
Human   873 ACIPWAYYSTVDQVKDLYSGL-IGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDN-I 935

  Fly   458 EVRQGEGFRFQMDDISF-SMPKMSLLQTRNLG------------VGQFFCNRSQQADLGFNCRQR 509
            :.......:...||..| ...||..:..|..|            |..:......:.||
Human   936 KTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDL------- 993

  Fly   510 HCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPLPRR 574
                                       |.:|.||::|:....||..
Human   994 ---------------------------HTVHFHGHSFQYKHRGVYS------------------- 1012

  Fly   575 AKGAPLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSENGMAAVVRV 624
                  .|...:....|..|..:..:||.|:.|||::.|...||.....|
Human  1013 ------SDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTV 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	97/571 (17%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	29/128 (23%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	19/147 (13%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	30/170 (18%)
CP	XP_011510737.1	CuRO_1_ceruloplasmin	22..202	CDD:259884
		CuRO_2_ceruloplasmin	214..354	CDD:259907
		CuRO_3_ceruloplasmin	369..572	CDD:259886	1/1 (100%)
		CuRO_4_ceruloplasmin	575..718	CDD:259908	34/162 (21%)
		CuRO_5_ceruloplasmin	732..902	CDD:259887	36/237 (15%)
		CuRO_6_ceruloplasmin	913..1057	CDD:259898	33/204 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12110
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010