DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mco4 and Heph

DIOPT Version :9

Sequence 1:	NP_573249.1	Gene:	Mco4 / 326221	FlyBaseID:	FBgn0052557	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_579838.1	Gene:	Heph / 117240	RGDID:	71060	Length:	1157	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	126/695 - (18%)
Similarity:	207/695 - (29%)	Gaps:	263/695 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LVFTLCLI----SVQIY--GIQDASGKRIVSKYERIMQMYPQLSSGAGESSQWRAAEKDNQRHPC 67
            |:.:||.:    :::.|  ||||.                           ||..|.|.
  Rat    12 LMHSLCSLPTDGAIRNYYLGIQDI---------------------------QWNYAPKG------ 43

  Fly    68 RRDCADKQPMTCYYYMVVHYDDTMAETCKRYLQSKFRFKLSGKEYIDGIALATQLAANDDCKYAD 132
             |:....|.:.         :||:|.:          |..|||..|.|....|...     :|:|
  Rat    44 -RNVITNQTLN---------NDTVASS----------FLKSGKNRIGGTYKKTVYK-----EYSD 83

  Fly   133 GLESEVMVVNGQL----PGMNIEVCYGDTVVADVINSMHETTTIHWHGMHQR------LTP---- 183
            |..:..:.....|    |.:..|:  ||.::..:.|......|||.||:...      |.|
  Rat    84 GTYTNEIAKPAWLGFLGPLLKAEM--GDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSS 146

  Fly   184 -FM---DGVP----HVTQYPIEAGQAFRYRFEVDHGGTNW-WHSHTEHQR--AFGLAGPLVV--- 234
             ::   |.||    ||..:.|..|.|   ..|.|.....| :|||.:..|  |.||.|||:.
  Rat   147 GYLKADDSVPPGGSHVYNWSIPEGHA---PTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKR 208

  Fly   235 -----RMPPKLNPHAH-------LYDFDMSEHVIMIQDWVHNFVESVAENILINGRGRNLKKGVK 287
                 ..||:.....|       :.|.::|.|   :.|.:..:....|.....:|..::..: :.
  Rat   209 GTLDGNSPPQRKDVDHNFFLLFSVIDENLSWH---LDDNIATYCSDPASVDKEDGPFQDSNR-MH 269

  Fly   288 AAKPTLYAHFPVVRGGRYRFRVIFNGVSNCPISFSIDKHDLVVIASDGNDIEPVEVQRIMFHG-- 350
            |....::.:.|                   .:|....||....:...||:|   :|....|||
  Rat   270 AINGFVFGNLP-------------------ELSMCAQKHVAWHLFGMGNEI---DVHTAFFHGQT 312

  Fly   351 ----AERFDFVLH------ANQEV----SNYWIRVKGYSFCAKNQLHQEAVLHYRDADTRALD-- 399
                ..|.| |.|      ...|:    |..|:     ..|..|...:..:..:...|:.::|
  Rat   313 LSIRGHRTD-VAHIFPATFVTAEMVPQKSGTWL-----ISCVVNSHLKSGMQAFYKVDSCSMDPP 371

  Fly   400 --------------THTLSYAYDAPGKTLNELGDDASGARAGNSISLANLNAQRPEPEVAPSVTF 450
                          .|.:.:.|       ..:|.|   .|.|.|:.         ||...|...|
  Rat   372 VEQLTGKVRQYFIQAHEIQWDY-------GPIGHD---GRTGKSLR---------EPGSGPDKYF 417

  Fly   451 YTSMN---------AFEVRQGEGFRFQMDDISFSMPKMSLLQTRNLGVGQFFCNRSQQADLGFNC 506
            ..|.:         .:|..|.|.|:.::                         ::.::..||.
  Rat   418 QKSSSRIGGTYWKVRYEAFQDETFQERL-------------------------HQEEETHLGI-- 455

  Fly   507 RQRHCQCSNVIQVPANQQVEFVISSLSQTPHPIHLHGYTFRVVGMGVLGEQKIGQIEQIDKKTPL 571
                  ...||:......::.|..:.:..|..|..||..:.
  Rat   456 ------LGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYE------------------------ 490

  Fly   572 PRRAKGAPLKDSVQVPAFGYTILRFYSNSPGYWMFHCHISPHSEN 616
             :.::|....|....|    .:.:.:.....||....|..|.:|:
  Rat   491 -KSSEGTVYNDGTSYP----KVAKSFEKVTYYWTVPPHAGPTAED 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mco4	NP_573249.1	ascorbase	132..626	CDD:274555	101/566 (18%)
		CuRO_1_tcLCC2_insect_like	132..235	CDD:259927	36/135 (27%)
		CuRO_2_tcLCC_insect_like	253..390	CDD:259951	25/152 (16%)
		CuRO_3_tcLLC2_insect_like	468..633	CDD:259972	17/149 (11%)
Heph	NP_579838.1	CuRO_1_ceruloplasmin	26..208	CDD:259884	58/244 (24%)
		Cupredoxin	223..363	CDD:418529	28/171 (16%)
		CuRO_3_ceruloplasmin	377..571	CDD:259886	33/235 (14%)
		Cupredoxin	574..717	CDD:418529
		CuRO_5_ceruloplasmin	732..903	CDD:259887
		Cupredoxin	919..1062	CDD:418529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11709
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010