DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32488 and PGP

DIOPT Version :9

Sequence 1:	NP_001286926.1	Gene:	CG32488 / 326220	FlyBaseID:	FBgn0052488	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001035830.1	Gene:	PGP / 283871	HGNCID:	8909	Length:	321	Species:	Homo sapiens

Alignment Length:	319	Identity:	97/319 - (30%)
Similarity:	159/319 - (49%)	Gaps:	37/319 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KLPKQRVRQWLSTFESVILDADGVLWHFSKAIDGAVDTFNYMNTTGRKIFIISNNSEISRQEMAD 75
            :|..:|.:..|:..::::.|.|||||....|:.||.:....:...|:::..|:|||..:|...|:
Human    15 RLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAE 79

  Fly    76 KAK--GFG--------IEIKEDNVLTSSFSCANFLAVKNFQK-------KVFVMGEKGVHFELEK 123
            |.:  |||        :|:         |..|...|:...|:       |.:|:|...:..|||.
Human    80 KLRRLGFGGPAGPGASLEV---------FGTAYCTALYLRQRLAGAPAPKAYVLGSPALAAELEA 135

  Fly   124 FGICSLKMS-EKL--EKP---MHEFVTELELDPDVGAVIVGRDEGFNMAKLVRTGSYLLNPDVIF 182
            .|:.|:.:. |.|  |.|   :|     ..|:|||.||:||.|..|:..||.:...||..|..:.
Human   136 VGVASVGVGPEPLQGEGPGDWLH-----APLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLL 195

  Fly   183 LGTCLDAAYPIGNNRVMVGAGATLAAMKAYTGRSPLVLGKPNPWMASTLMQSGAIKPETTLMVGD 247
            :||.:|...|:.|.|.:.|.|..:.|::....|...::|||:.::...:.|...|.||.|:||||
Human   196 VGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGD 260

  Fly   248 TLQTDMHFASNCGFQSLMVGSGVNTPKEVQQIIEEGDPKKKILVPDTYLPSLGHMLEFL 306
            .|.||:...:.||.::::..:||:|..:|:...|.....||.:|||.|:.|:..:|..|
Human   261 RLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPAL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32488	NP_001286926.1	PGP_euk	23..300	CDD:273635	92/299 (31%)
		Hydrolase_6	27..127	CDD:290083	32/116 (28%)
		Hydrolase_like	219..285	CDD:289983	22/65 (34%)
PGP	NP_001035830.1	PGP_euk	28..315	CDD:273635	92/300 (31%)
		Hydrolase_6	31..138	CDD:290083	31/115 (27%)
		Hydrolase_like	232..315	CDD:289983	29/82 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149847
Domainoid	1	1.000	68	1.000	Domainoid score	I9707
eggNOG	1	0.900	-	-		E1_COG0647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1709
OMA	1	1.010	-	-		QHG60740
OrthoDB	1	1.010	-	-		D337140at33208
OrthoFinder	1	1.000	-	-		FOG0000783
OrthoInspector	1	1.000	-	-		mtm8596
orthoMCL	1	0.900	-	-		OOG6_100677
Panther	1	1.100	-	-	O	PTHR19288
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R944
SonicParanoid	1	1.000	-	-		X675
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790